Long-Range Electron Transfer through DNA Films

Long-Range Electron Transfer through DNA Films

Regardless of its position within the DNA film, cross‐linked daunomycin (DM) is efficiently reduced electrochemically, indicating that the electron transfer exhibits a shallow distance dependence. Upon the introduction of an intervening cytosine–adenine (CA) mismatch, the electrochemical response is...

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Veröffentlicht in:Angewandte Chemie International Edition 1999-04, Vol.38 (7), p.941-945
Hauptverfasser: Kelley, Shana O., Jackson, Nicole M., Hill, Michael G., Barton, Jacqueline K.
Format: Artikel
Sprache:eng
Schlagworte:
Biosensors
Cyclic voltammetry
DNA structures
Electron transfer
Monolayers
Thin films
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Zusammenfassung:Regardless of its position within the DNA film, cross‐linked daunomycin (DM) is efficiently reduced electrochemically, indicating that the electron transfer exhibits a shallow distance dependence. Upon the introduction of an intervening cytosine–adenine (CA) mismatch, the electrochemical response is dramatically attenuated (shown schematically). Therefore, the DNA double helix can facilitate long‐range electron transfer, but only in the presence of a well‐stacked pathway.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19990401)38:7<941::AID-ANIE941>3.0.CO;2-7