Serial [5+2]/[4+2] Cycloadditions: Facile, Preparative, Multi-Component Syntheses of Polycyclic Compounds from Simple, Readily Available Starting Materials

Serial [5+2]/[4+2] Cycloadditions: Facile, Preparative, Multi-Component Syntheses of Polycyclic Compounds from Simple, Readily Available Starting Materials

Four new bonds and up to four new stereocenters are formed in the title reactions which allow the conversion of readily available starting materials into complex bicyclo[5.4.0]undecane derivatives (see scheme). The reactions are performed in a single, simple operation that can be conducted on a prep...

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Veröffentlicht in:Angewandte Chemie International Edition 2001-10, Vol.40 (20), p.3895-3897
Hauptverfasser: Wender, Paul A., Gamber, Gabriel G., Scanio, Marc J. C.
Format: Artikel
Sprache:eng
Schlagworte:
chemoselectivity
cycloaddition
enynes
rhodium
tandem reactions
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Zusammenfassung:Four new bonds and up to four new stereocenters are formed in the title reactions which allow the conversion of readily available starting materials into complex bicyclo[5.4.0]undecane derivatives (see scheme). The reactions are performed in a single, simple operation that can be conducted on a preparative scale (100 mmol thus far).
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20011015)40:20<3895::AID-ANIE3895>3.0.CO;2-#