Selective RGD-Mediated Adhesion of Osteoblasts at Surfaces of Implants

Selective RGD-Mediated Adhesion of Osteoblasts at Surfaces of Implants

Osteoblasts: yes, platelets: no! Bone implants have to be integrated with the surrounding tissue to allow a smooth and stable connection. A new procedure is shown which is based on covalent linking of a highly selective RGD peptide to a poly(methyl methacrylate) (PMMA) material (see picture). Osteob...

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Veröffentlicht in:Angewandte Chemie International Edition 1999-02, Vol.38 (4), p.560-562
Hauptverfasser: Kantlehner, Martin, Finsinger, Dirk, Meyer, Jörg, Schaffner, Patricia, Jonczyk, Alfred, Diefenbach, Beate, Nies, Berthold, Kessler, Horst
Format: Artikel
Sprache:eng
Schlagworte:
Bioorganic chemistry
Integrins
Materials science
Peptides
Surface chemistry
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Zusammenfassung:Osteoblasts: yes, platelets: no! Bone implants have to be integrated with the surrounding tissue to allow a smooth and stable connection. A new procedure is shown which is based on covalent linking of a highly selective RGD peptide to a poly(methyl methacrylate) (PMMA) material (see picture). Osteoblasts very effectively bind to the treated surface and are stimulated to proliferate.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19990215)38:4<560::AID-ANIE560>3.0.CO;2-F