Catalytic Enantioselective Fluorination of β-Ketoesters

Isolated and crystallized [Ti(TADDOLato)] complexes were used as catalysts for the first catalytic enantioselective (up to 90 % ee) C−F bond‐forming reaction, the fluorination of β‐ketoesters with the N‐fluorotriethylenediammonium salt F‐TEDA [Eq. (1)]. TADDOL=2,2‐dimethyl‐α,α,α′,α′‐tetraaryl‐1,3‐di...

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Veröffentlicht in:	Angewandte Chemie International Edition 2000-12, Vol.39 (23), p.4359-4362
Hauptverfasser:	Hintermann, Lukas, Togni, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric catalysis fluorine TADDOL titanium
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Isolated and crystallized [Ti(TADDOLato)] complexes were used as catalysts for the first catalytic enantioselective (up to 90 % ee) C−F bond‐forming reaction, the fluorination of β‐ketoesters with the N‐fluorotriethylenediammonium salt F‐TEDA [Eq. (1)]. TADDOL=2,2‐dimethyl‐α,α,α′,α′‐tetraaryl‐1,3‐dioxolan‐4,5‐dimethanol.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/1521-3773(20001201)39:23<4359::AID-ANIE4359>3.0.CO;2-P