A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-Aminoimidazoles

A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-Aminoimidazoles

When general and reliable, multicomponent reactions are among the most powerful tools in modern drug discovery. The principle of chemical ligation of reactive partners (see reaction scheme) has been employed to find a new, highly efficient synthesis of fused 3‐aminoimidazoles.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 1998-09, Vol.37 (16), p.2234-2237
Hauptverfasser: Bienaymé, Hugues, Bouzid, Kamel
Format: Artikel
Sprache:eng
Schlagworte:
Combinatorial chemistry
Cycloadditions
Heterocycles
Multicomponent reactions
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Beschreibung
Zusammenfassung:When general and reliable, multicomponent reactions are among the most powerful tools in modern drug discovery. The principle of chemical ligation of reactive partners (see reaction scheme) has been employed to find a new, highly efficient synthesis of fused 3‐aminoimidazoles.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19980904)37:16<2234::AID-ANIE2234>3.0.CO;2-R