Dual Recognition of Double-Stranded DNA by 2′-Aminoethoxy-Modified Oligonucleotides

Dual Recognition of Double-Stranded DNA by 2′-Aminoethoxy-Modified Oligonucleotides

Simultaneous interaction of the 2′‐aminoethoxy‐modified oligonucleotides with the phosphodiester backbone (shown on the right, A) and with the bases through Hoogsteen base contacts (B) is seen at each base‐pair step of the duplex DNA target. The electrostatic interaction between the protonated amino...

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Veröffentlicht in:Angewandte Chemie International Edition 1998-05, Vol.37 (9), p.1288-1291
Hauptverfasser: Cuenoud, Bernard, Casset, Florence, Hüsken, Dieter, Natt, François, Wolf, Romain M., Altmann, Karl-Heinz, Martin, Pierre, Moser, Heinz E.
Format: Artikel
Sprache:eng
Schlagworte:
Bioorganic chemistry
DNA recognition
Molecular recognition
Oligonucleotides
Triple helices
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Beschreibung
Zusammenfassung:Simultaneous interaction of the 2′‐aminoethoxy‐modified oligonucleotides with the phosphodiester backbone (shown on the right, A) and with the bases through Hoogsteen base contacts (B) is seen at each base‐pair step of the duplex DNA target. The electrostatic interaction between the protonated amino group and the negatively charged phosphate group provides for a dramatic increase in the binding affinity and the association rate constant.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19980518)37:9<1288::AID-ANIE1288>3.0.CO;2-U