Supramolecular Catalysis of Ester and Amide Cleavage by a Dinuclear Barium(II) Complex

Supramolecular Catalysis of Ester and Amide Cleavage by a Dinuclear Barium(II) Complex

Five components spontaneously self‐assemble to yield the productive complex 1, where one barium ion delivers an ethoxide to the carbonyl group of an amide substrate anchored by means of a distal carboxylate moiety to the other barium ion. High substrate specificity, fairly high reaction rates with c...

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Veröffentlicht in:Angewandte Chemie International Edition 1999-02, Vol.38 (3), p.348-351
Hauptverfasser: Cacciapaglia, Roberta, Di Stefano, Stefano, Kelderman, Erik, Mandolini, Luigi
Format: Artikel
Sprache:eng
Schlagworte:
Alkaline earth metals
Enzyme mimetics
Macrocyclic ligands
Supramolecular chemistry
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Zusammenfassung:Five components spontaneously self‐assemble to yield the productive complex 1, where one barium ion delivers an ethoxide to the carbonyl group of an amide substrate anchored by means of a distal carboxylate moiety to the other barium ion. High substrate specificity, fairly high reaction rates with catalytic turnover, and competitive inhibition by inert substrates are observed.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19990201)38:3<348::AID-ANIE348>3.0.CO;2-D