Expanding the Potential of DNA for Binding and Catalysis: Highly Functionalized dUTP Derivatives That Are Substrates for Thermostable DNA Polymerases

Expanding the Potential of DNA for Binding and Catalysis: Highly Functionalized dUTP Derivatives That Are Substrates for Thermostable DNA Polymerases

The discovery of a simple structural motif allows for the enzymatic synthesis by polymerase chain reactions (PCR) of modified DNA (see reaction scheme) bearing side chains similar or even identical to those of several amino acids. Libraries of DNA functionalized with both cationic and anionic groups...

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Veröffentlicht in:Angewandte Chemie International Edition 1998-11, Vol.37 (20), p.2872-2875
Hauptverfasser: Sakthivel, Kandasamy, Barbas III, Carlos F.
Format: Artikel
Sprache:eng
Schlagworte:
Aptamers
Combinatorial chemistry
DNA-enzymes
In vitro selection
Nucleotides
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Beschreibung
Zusammenfassung:The discovery of a simple structural motif allows for the enzymatic synthesis by polymerase chain reactions (PCR) of modified DNA (see reaction scheme) bearing side chains similar or even identical to those of several amino acids. Libraries of DNA functionalized with both cationic and anionic groups may now be readily prepared. R=I, HgCl; X=functional group.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19981102)37:20<2872::AID-ANIE2872>3.0.CO;2-5