Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Regioselective halogenations and Suzuki reactions ensure proper linkage of the aromatic rings in two total syntheses of terprenin (1). Both routes make it possible to prepare 1 efficiently and in large quantity.

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Veröffentlicht in:Angewandte Chemie International Edition 1998-04, Vol.37 (7), p.973-975
Hauptverfasser: Kawada, Kenji, Arimura, Akinori, Tsuri, Tatsuo, Fuji, Masahiro, Komurasaki, Tadafumi, Yonezawa, Shuji, Kugimiya, Akira, Haga, Nobuhiro, Mitsumori, Susumu, Inagaki, Masanao, Nakatani, Takuji, Tamura, Yoshinori, Takechi, Shozo, Taishi, Teruhiko, Kishino, Junji, Ohtani, Mitsuaki
Format: Artikel
Sprache:eng
Schlagworte:
Cross-coupling
Immunosuppressants
Natural products
Terprenin
Total synthesis
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Beschreibung
Zusammenfassung:Regioselective halogenations and Suzuki reactions ensure proper linkage of the aromatic rings in two total syntheses of terprenin (1). Both routes make it possible to prepare 1 efficiently and in large quantity.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19980420)37:7<973::AID-ANIE973>3.0.CO;2-T