Enantioselective Hydrogenation of Olefins with Iridium-Phosphanodihydrooxazole Catalysts

Enantioselective Hydrogenation of Olefins with Iridium-Phosphanodihydrooxazole Catalysts

High turnover numbers and up to 98% ee were obtained in the catalytic hydrogenation of unfunctionalized aryl‐substituted olefins with iridium–phosphanyldihydrooxazole complexes 1 (see reaction scheme). The anion of the complex—for example, hexafluorophosphate or tetrakis[3,5‐bis(trifluoromethyl)phen...

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Veröffentlicht in:Angewandte Chemie International Edition 1998-11, Vol.37 (20), p.2897-2899
Hauptverfasser: Lightfoot, Andrew, Schnider, Patrick, Pfaltz, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetric catalysis
Dihydrooxazoles
Hydrogenations
Iridium
N ligands
P ligands
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Zusammenfassung:High turnover numbers and up to 98% ee were obtained in the catalytic hydrogenation of unfunctionalized aryl‐substituted olefins with iridium–phosphanyldihydrooxazole complexes 1 (see reaction scheme). The anion of the complex—for example, hexafluorophosphate or tetrakis[3,5‐bis(trifluoromethyl)phenyl]borate (BARF−)—has a remarkable effect on the reactivity and longevity of the catalyst.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19981102)37:20<2897::AID-ANIE2897>3.0.CO;2-8