Methyl Transfer from Methanol to Co-cobyrinate: A model for the Coenzyme B12 Dependent Methyltransferase?

Methyl Transfer from Methanol to Co-cobyrinate: A model for the Coenzyme B12 Dependent Methyltransferase?

With CoI corrins as supernucleophiles, methylation by methanol is achieved when the leaving group is activated by Zn2+ ions at elevated temperatures (see reaction below). This methylation reaction is the first model for the Co‐dependent methyltransferase.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 1998-05, Vol.37 (9), p.1283-1285
Hauptverfasser: Schnyder, Alexander, Darbre, Tamis, Keese, Reinhart
Format: Artikel
Sprache:eng
Schlagworte:
Alkylations
Corrins
Enzyme models
Lewis acids
Supernucleophiles
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Beschreibung
Zusammenfassung:With CoI corrins as supernucleophiles, methylation by methanol is achieved when the leaving group is activated by Zn2+ ions at elevated temperatures (see reaction below). This methylation reaction is the first model for the Co‐dependent methyltransferase.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19980518)37:9<1283::AID-ANIE1283>3.0.CO;2-N