Use of Lewis Acids in Free Radical Reactions

Use of Lewis Acids in Free Radical Reactions

The neglect of free radicals over the past few years has been overcome, and they are no longer only considered as interesting reactive intermediates with limited synthetic potential. New opportunities are opened up by performing radical reactions in the presence of Lewis acids. Rate enhancement of r...

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Veröffentlicht in:Angewandte Chemie International Edition 1998-10, Vol.37 (19), p.2562-2579
Hauptverfasser: Renaud, Philippe, Gerster, Michèle
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetric synthesis
Chelates
Lewis acids
Radical reactions
Radicals
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Beschreibung
Zusammenfassung:The neglect of free radicals over the past few years has been overcome, and they are no longer only considered as interesting reactive intermediates with limited synthetic potential. New opportunities are opened up by performing radical reactions in the presence of Lewis acids. Rate enhancement of radical addition to olefins as well as stereochemical control of such reactions can be achieved in a unique manner. Recent examples of enantioselective radical reactions and perspectives for applications in catalysis are discussed.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19981016)37:19<2562::AID-ANIE2562>3.0.CO;2-D