An Access to Glycoconjugate Libraries through Multicomponent Reactions

An Access to Glycoconjugate Libraries through Multicomponent Reactions

Four‐component reactions: The Ugi reaction of four suitably functionalized carbohydrate derivatives (as a per‐O‐benzylated amine, an aldehyde, a carboxylic acid, and an isocyanide) allow the effective assembly of diverse compound libraries. The complex glycoconjugates formed can be deprotected (see...

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Veröffentlicht in:Angewandte Chemie International Edition 1998-12, Vol.37 (24), p.3436-3439
1. Verfasser: Lockhoff, Oswald
Format: Artikel
Sprache:eng
Schlagworte:
Carbohydrates
Combinatorial chemistry
Glycoconjugates
Glycomimetics
Multicomponent reactions
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Beschreibung
Zusammenfassung:Four‐component reactions: The Ugi reaction of four suitably functionalized carbohydrate derivatives (as a per‐O‐benzylated amine, an aldehyde, a carboxylic acid, and an isocyanide) allow the effective assembly of diverse compound libraries. The complex glycoconjugates formed can be deprotected (see the picture for an example), and the resulting glycomimetics are of high interest for screening purposes.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19981231)37:24<3436::AID-ANIE3436>3.0.CO;2-Z