PNA: Synthetic Polyamide Nucleic Acids with Unusual Binding Properties

PNA: Synthetic Polyamide Nucleic Acids with Unusual Binding Properties

The astonishing discovery that peptide nucleic acids (PNAs, B=nucleobase), in spite of their drastic structural difference to natural DNA, are better nucleic acid mimetics than many other oligonucleotides has resulted in an explosion of research into this class of compounds. The synthesis, physical...

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Veröffentlicht in:Angewandte Chemie International Edition 1998-11, Vol.37 (20), p.2796-2823
Hauptverfasser: Uhlmann, Eugen, Peyman, Anusch, Breipohl, Gerhard, Will, David W.
Format: Artikel
Sprache:eng
Schlagworte:
Antisense agents
DNA recognition
Gene technology
Molecular recognition
Peptide nucleic acids
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Zusammenfassung:The astonishing discovery that peptide nucleic acids (PNAs, B=nucleobase), in spite of their drastic structural difference to natural DNA, are better nucleic acid mimetics than many other oligonucleotides has resulted in an explosion of research into this class of compounds. The synthesis, physical properties, and biological interactions of PNAs as well as their chimeras with DNA and RNA are summarized here.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19981102)37:20<2796::AID-ANIE2796>3.0.CO;2-K