Self-Repairing DNA Based on a Reductive Electron Transfer through the Base Stack

Self-Repairing DNA Based on a Reductive Electron Transfer through the Base Stack

Cycloreversion of the highly mutagenic UV‐induced cyclobutane pyrimidine dimer lesion in DNA occurs by a light‐induced transfer of an electron through the base stack from a flavin electron donor to the lesion (see schematic representation). This process is even effective when the DNA lesion and flav...

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Veröffentlicht in:Angewandte Chemie International Edition 2000-11, Vol.39 (21), p.3918-3920
Hauptverfasser: Schwögler, Anja, Burgdorf, Lars T., Carell, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
DNA repair
electron transfer
fluorescence spectroscopy
photolyases
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Beschreibung
Zusammenfassung:Cycloreversion of the highly mutagenic UV‐induced cyclobutane pyrimidine dimer lesion in DNA occurs by a light‐induced transfer of an electron through the base stack from a flavin electron donor to the lesion (see schematic representation). This process is even effective when the DNA lesion and flavin donor are separated by an intervening base pair.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20001103)39:21<3918::AID-ANIE3918>3.0.CO;2-6