Relationship between brain and ovary aromatase activity and isoform-specific aromatase mRNA expression in the fathead minnow ( Pimephales promelas)

There is growing evidence that some chemicals present in the environment have the capacity to inhibit, or potentially induce, aromatase activity. This study compared aromatase activities and isoform-specific mRNA expression in brain and ovary tissue from non-exposed fathead minnows representing thre...

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Veröffentlicht in:	Aquatic toxicology 2006-03, Vol.76 (3), p.353-368
Hauptverfasser:	Villeneuve, Daniel L., Knoebl, Iris, Kahl, Michael D., Jensen, Kathleen M., Hammermeister, Dean E., Greene, Katie J., Blake, Lindsey S., Ankley, Gerald T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Aromatase - biosynthesis Aromatase - drug effects Aromatase - genetics Aromatase inhibitor Aromatase Inhibitors - toxicity Biological and medical sciences brain Brain - drug effects Brain - enzymology brain aromatase Cyprinidae - metabolism cytochrome P-450 DNA Primers - chemistry Dose-Response Relationship, Drug Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates endocrine-disrupting chemicals enzyme activity enzyme inhibition enzyme inhibitors Fadrozole Fadrozole - toxicity Fathead minnow Female Freshwater Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - physiology Male messenger RNA minnows ovaries Ovary - drug effects Ovary - enzymology ovary aromatase Pimephales promelas Polymerase Chain Reaction - veterinary Protein Isoforms - physiology Q-PCR Real-time PCR Reproduction RNA, Messenger - analysis Teleostei water pollution
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