Oxyrane derivative of α-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms

The investigation of trypanocidal effects against Trypanosoma cruzi and cytotoxicity in VERO cell line of several oxyranes structurally related to beta-lapachone, nor-beta-lapachone, alpha-lapachone, and 4-methoxy-1,2-naphthoquinone is described. It was found that the oxyranes 10 derived from alpha-...

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Veröffentlicht in:	Parasitology research (1987) 2006-09, Vol.99 (4), p.429-433
Hauptverfasser:	JORQUEIRA, Alessandra, GOUVEA, Robson M, FERREIRA, Vitor F, DA SILVA, Milton N, DE SOUZA, Maria C. B. V, ZUMA, Aline A, CAVALCANTI, Danielle F. B, ARAUJO, Humberto P, SANTOS, Dilvani O, BOURGUIGNON, Saulo C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal Agents - pharmacology Biological and medical sciences Cell Survival - drug effects Cercopithecus aethiops Dose-Response Relationship, Drug Fibroblasts - drug effects Fibroblasts - pathology Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Growth Inhibitors - pharmacology Invertebrates Naphthoquinones - chemistry Naphthoquinones - pharmacology Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - growth & development Vero Cells
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Zusammenfassung:	The investigation of trypanocidal effects against Trypanosoma cruzi and cytotoxicity in VERO cell line of several oxyranes structurally related to beta-lapachone, nor-beta-lapachone, alpha-lapachone, and 4-methoxy-1,2-naphthoquinone is described. It was found that the oxyranes 10 derived from alpha-lapachone showed an approximately the same trypanocidal activity of beta-lapachone. In addition, all the oxyranes showed less cytotoxicity than the corresponding naphthoquinones.
ISSN:	0932-0113 1432-1955
DOI:	10.1007/s00436-006-0153-8