Randomized controlled trials in pediatric patients had higher completion rates than adult trials: a cross-sectional study

Conduct of clinical trials is perceived to be more challenging in children than in adults. This study aimed to evaluate the impact of the age of participants on completion rates of randomized controlled trials (RCTs). A cross-sectional study on RCTs registered in the ClinicalTrials.gov database. All...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical epidemiology 2018-08, Vol.100, p.53-60
Hauptverfasser:	Dufetelle, Edouard, ‘t Jong, Geert W., Kaguelidou, Florentia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Adult Adults Age Child Child, Preschool Children Clinical trials Completion rates Cross-Sectional Studies Early Termination of Clinical Trials - economics Early Termination of Clinical Trials - statistics & numerical data Epidemiology Ethics Funding Humans Infant Intervention Logistic Models Medical research Multivariate analysis Odds Ratio Patient Selection Pediatric research Pediatrics Premature discontinuation Randomization Randomized controlled trials Randomized Controlled Trials as Topic - economics Regression models Teenagers Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Conduct of clinical trials is perceived to be more challenging in children than in adults. This study aimed to evaluate the impact of the age of participants on completion rates of randomized controlled trials (RCTs). A cross-sectional study on RCTs registered in the ClinicalTrials.gov database. All RCTs registered up to December 31, 2016, were extracted and were classified according to their recruitment status: active, completed, or discontinued and according to the age of participants: children (
ISSN:	0895-4356 1878-5921
DOI:	10.1016/j.jclinepi.2018.04.018