Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke

In a randomized trial involving patients with acute stroke, the incidence of revascularization was higher with tenecteplase than with alteplase for intravenous thrombolysis before endovascular thrombectomy. Cerebral hemorrhage occurred at the same rate in each group.

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Veröffentlicht in:	The New England journal of medicine 2018-04, Vol.378 (17), p.1573-1582
Hauptverfasser:	Campbell, Bruce C.V, Mitchell, Peter J, Churilov, Leonid, Yassi, Nawaf, Kleinig, Timothy J, Dowling, Richard J, Yan, Bernard, Bush, Steven J, Dewey, Helen M, Thijs, Vincent, Scroop, Rebecca, Simpson, Marion, Brooks, Mark, Asadi, Hamed, Wu, Teddy Y, Shah, Darshan G, Wijeratne, Tissa, Ang, Timothy, Miteff, Ferdinand, Levi, Christopher R, Rodrigues, Edrich, Zhao, Henry, Salvaris, Patrick, Garcia-Esperon, Carlos, Bailey, Peter, Rice, Henry, de Villiers, Laetitia, Brown, Helen, Redmond, Kendal, Leggett, David, Fink, John N, Collecutt, Wayne, Wong, Andrew A, Muller, Claire, Coulthard, Alan, Mitchell, Ken, Clouston, John, Mahady, Kate, Field, Deborah, Ma, Henry, Phan, Thanh G, Chong, Winston, Chandra, Ronil V, Slater, Lee-Anne, Krause, Martin, Harrington, Timothy J, Faulder, Kenneth C, Steinfort, Brendan S, Bladin, Christopher F, Sharma, Gagan, Desmond, Patricia M, Parsons, Mark W, Donnan, Geoffrey A, Davis, Stephen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Body weight Brain Ischemia - drug therapy Brain research Cardiovascular system Carotid arteries Cerebral blood flow Cerebral Hemorrhage - chemically induced Combined Modality Therapy Consent Drug dosages Endovascular Procedures Female Fibrin Fibrinolytic Agents - adverse effects Fibrinolytic Agents - therapeutic use Hemorrhage Humans Intravenous administration Ischemia Logistic Models Male Medical imaging Medical research Middle Aged Neurology Reperfusion Reperfusion - methods Severity of Illness Index Single-Blind Method Stroke Stroke - drug therapy Stroke - mortality Stroke - surgery Tenecteplase Territory Thrombectomy Thrombolysis Thrombolytic drugs Thrombosis Time-to-Treatment Tissue Plasminogen Activator - adverse effects Tissue Plasminogen Activator - therapeutic use Veins & arteries
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Beschreibung
Zusammenfassung:	In a randomized trial involving patients with acute stroke, the incidence of revascularization was higher with tenecteplase than with alteplase for intravenous thrombolysis before endovascular thrombectomy. Cerebral hemorrhage occurred at the same rate in each group.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1716405