CRISPR genetic screens to discover host–virus interactions

Viruses impose an immense burden on human health. With the goal of treating and preventing viral infections, researchers have carried out genetic screens to improve our understanding of viral dependencies and identify potential anti-viral strategies. The emergence of CRISPR genetic screening tools h...

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Veröffentlicht in:Current opinion in virology 2018-04, Vol.29, p.87-100
Hauptverfasser: .McDougall, William M, Perreira, Jill M, Reynolds, Erin C, Brass, Abraham L
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Sprache:eng
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Zusammenfassung:Viruses impose an immense burden on human health. With the goal of treating and preventing viral infections, researchers have carried out genetic screens to improve our understanding of viral dependencies and identify potential anti-viral strategies. The emergence of CRISPR genetic screening tools has facilitated this effort by enabling host–virus screens to be undertaken in a more versatile and fidelitous manner than previously possible. Here we review the growing number of CRISPR screens which continue to increase our understanding of host–virus interactions.
ISSN:1879-6257
1879-6265
DOI:10.1016/j.coviro.2018.03.007