Imaging pediatric gastrointestinal stromal tumor (GIST)

Gastrointestinal stromal tumors (GIST) are extremely rare in children. Imaging plays a key role in staging and monitoring therapy (surgical and with tyrosine kinase inhibitors). The vast majority of articles addressing imaging of GIST base on adults and are based on CT. The subtype “pediatric GIST”...

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Veröffentlicht in:Journal of pediatric surgery 2018-09, Vol.53 (9), p.1862-1870
Hauptverfasser: Herzberg, Moriz, Beer, Meinrad, Anupindi, Sudha, Vollert, Kurt, Kröncke, Thomas
Format: Artikel
Sprache:eng
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Zusammenfassung:Gastrointestinal stromal tumors (GIST) are extremely rare in children. Imaging plays a key role in staging and monitoring therapy (surgical and with tyrosine kinase inhibitors). The vast majority of articles addressing imaging of GIST base on adults and are based on CT. The subtype “pediatric GIST” – if at all – is only mentioned in a dependent clause. Although the imaging features in children and adults are similar, histology, clinical course and thus imaging approach are different. A PubMed search using the search terms “Gastrointestinal stromal tumor, GIST, WT GIST, children, pediatric, carney’s triad, imaging, staging, follow-up, MRI, CEUS, ultrasonography, Positron emission tomography” was conducted. Studies that reported on laparoscopy, endoscopy and surgical techniques only were excluded. Based on our selective literature review, we present alternative radiological imaging strategies using MRI, contrast enhanced ultrasound (CEUS) and PET–CT to stage and follow-up pediatric GIST patients. As pediatric GIST often is a chronic disease, minimizing exposure to ionizing radiation is mandatory. MRI, contrast enhanced ultrasound and PET–CT instead of CT are the imaging modalities to evaluate pediatric GIST. Systematic review III
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2018.03.022