Parkin mediates mitophagy during beige-to-white fat conversion

Parkin mediates mitophagy during beige-to-white fat conversion

In this issue of , Lu reveal a role for Parkin-mediated mitophagy in beige-to-white adipocyte transition. In the absence of Parkin, mitochondria in thermogenic beige adipocytes are preserved even after the elimination of cold mimetic stimuli-in contrast to their typical elimination during the white...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Science signaling 2018-04, Vol.11 (527)
Hauptverfasser: Sarraf, Shireen A, Youle, Richard J
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes, Beige
Adipose Tissue, White
Mitophagy
Parkin protein
Thermogenesis
Ubiquitin-Protein Ligases
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In this issue of , Lu reveal a role for Parkin-mediated mitophagy in beige-to-white adipocyte transition. In the absence of Parkin, mitochondria in thermogenic beige adipocytes are preserved even after the elimination of cold mimetic stimuli-in contrast to their typical elimination during the white transition.
ISSN:1945-0877
1937-9145
DOI:10.1126/scisignal.aat1082