Optimization of the method of the content‐containing interaction evaluation for cosmetic products by gas chromatography–mass spectrometry

In July 2013, the European Regulation (EC) No 1223/2009 came into effect in order to secure cosmetic products. The content‐containing interaction between the packaging and the product must be considered for the safety assessment. Indeed, some compounds are able to migrate from the packaging to the p...

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Veröffentlicht in:International journal of cosmetic science 2018-06, Vol.40 (3), p.269-275
Hauptverfasser: Charron, C., De Vaugelade, S., Richard, F., Largitte, A., Pirnay, S.
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Sprache:eng
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Zusammenfassung:In July 2013, the European Regulation (EC) No 1223/2009 came into effect in order to secure cosmetic products. The content‐containing interaction between the packaging and the product must be considered for the safety assessment. Indeed, some compounds are able to migrate from the packaging to the product and may be harmful to the consumer health. This is why a first test was established by EXPERTOX laboratory in 2012 to deal with this new regulation. A new analytical method was developed and validated for the quantification of 23 substances able to migrate from the packaging to the product. It was applied on a plastic packaging with the five simulants of migration. To evaluate the content‐containing interaction, a gas chromatography‐mass spectrometry method was developed and validated. Liquid–liquid extraction was used to extract contaminants (thirteen phthalates and ten substances of very high concern) from migration simulants. Calibration curves showed good linearity regression from 2 to 50 μg mL−1 for nineteen molecules and from 5 to 45 μg mL−1 for the others. The limits of quantification were respectively 2 and 5 μg mL−1. The accuracy, precision, repeatability of the analytical method and extraction yields were acceptable. No molecule was found in simulants of migration, so the potential contaminants present in the packaging did not migrate. A gas chromatography‐mass spectrometry method and liquid‐liquid extraction were validated for 23 molecules and can be used for the evaluation of the content‐containing interaction of cosmetic products. Both quantification and extraction procedures are more robust and faster than previous method. Résumé En juillet 2013, le règlement européen (CE) n° 1223/2009 est entré en vigueur afin de sécuriser les produits cosmétiques. L'interaction contenu‐contenant entre l'emballage et le produit doit être considérée dans l’évaluation de la sécurité. En effet, certains composés peuvent migrer de l'emballage vers le produit et peuvent nuire à la santé du consommateur. C'est pourquoi un premier test a été établi par le laboratoire EXPERTOX en 2012 pour faire face à cette nouvelle réglementation. Une nouvelle méthode de quantification de vingt‐trois substances capables de migrer de l'emballage vers le produit a été développée et validée. Celle‐ci a été appliquée sur un emballage en plastique avec les cinq simulants de migration. Pour évaluer l'interaction contenu‐contenant, une méthode par chromatographie en phase gazeuse couplé
ISSN:0142-5463
1468-2494
DOI:10.1111/ics.12460