Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy
Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, and levels of CMV-reactive antibody to assess the persiste...
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| Veröffentlicht in: | Viral immunology 2018-07, Vol.31 (6), p.472-479 |
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| creator | Ariyanto, Ibnu A. Estiasari, Riwanti Waters, Shelley Wulandari, Endah A.T. Fernandez, Sonia Lee, Silvia Price, Patricia |
| description | Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, and levels of CMV-reactive antibody to assess the persistent burden of CMV in a longitudinal study of 78 young adult patients beginning ART in Jakarta, Indonesia, with |
| doi_str_mv | 10.1089/vim.2018.0014 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2030914114</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2068005045</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-b9547014c19ed1f52d91981de734945c376686db27e8ca1d60e0d6a55a2505343</originalsourceid><addsrcrecordid>eNqFkTFr3DAUgEVpaK5px65F0KWLL0-2JMvjYdLmIJAMl0Ino7OeUwVbukrywQ3975W5tEOXThLSx8d7fIR8YLBmoJrro53WJTC1BmD8FVkxIepCNbV8TVagVFmokotL8jbGZwBQUlVvyGXZSKUUhxX5temTPSLVztAHDNHGhC7R9pT8hE969Ecb5ki3bsAMehfpZliudEdbHMdIraPf_eye6MbMY6K322_0QSebJZG2fprQ9Xb5dckGTGHx6ZHufmDQh9M7cjHoMeL7l_OKPH652bW3xd391227uSt6DjwV-0bwOq_XswYNG0RpGtYoZrCueMNFX9VSKmn2ZY2q18xIQDBSC6FLAaLi1RX5fPYegv85Y0zdZGOf59cO_Ry7EipoGGdsQT_9gz77Obg8XaakAhDARaaKM9UHH2PAoTsEO-lw6hh0S5cud-mWLt3SJfMfX6zzfkLzl_4TIgPVGVietXOjxT2G9B_tb7R9meE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2068005045</pqid></control><display><type>article</type><title>Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy</title><source>Alma/SFX Local Collection</source><creator>Ariyanto, Ibnu A. ; Estiasari, Riwanti ; Waters, Shelley ; Wulandari, Endah A.T. ; Fernandez, Sonia ; Lee, Silvia ; Price, Patricia</creator><creatorcontrib>Ariyanto, Ibnu A. ; Estiasari, Riwanti ; Waters, Shelley ; Wulandari, Endah A.T. ; Fernandez, Sonia ; Lee, Silvia ; Price, Patricia</creatorcontrib><description>Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, and levels of CMV-reactive antibody to assess the persistent burden of CMV in a longitudinal study of 78 young adult patients beginning ART in Jakarta, Indonesia, with <200 CD4 T cells/
μ
L. CMV antibodies, inflammatory markers (C-reactive protein [CRP], soluble interferon-
α
/
β
receptor) and T cell phenotypes were assessed before ART (V0) and after 1, 3, 6, and 12 months (V1–V12). CMV DNA was detected in 41 patients (52%) at V0, irrespective of CD4 T cell counts, gender, age, or plasma HIV RNA. CMV DNA+ patients had higher levels of antibody reactive with CMV Immediate Early 1 (IE-1) at V0 and V12 (
p
= 0.04), and with CMV lysate at V12 (
p
= 0.01). Detectable CMV DNA did not align with inflammatory markers, but associated with lower CD4/CD8 ratios until V3. CMV antibody levels correlated inversely with proportions of naive CD4 and CD8 T cells, and directly with proportions of CD57
+
and activated memory T cells (CD3
+
CD45RA
−
) after 3–12 months on ART. Overall, active CMV replication is common in HIV patients beginning ART in Indonesia and associates with low CD4/CD8 ratios. Elevated levels of CMV-reactive antibody measured on ART also mark a depletion of naive T cells, accumulation of memory T cells, and may be a stable metric of the burden of CMV.</description><identifier>ISSN: 0882-8245</identifier><identifier>EISSN: 1557-8976</identifier><identifier>DOI: 10.1089/vim.2018.0014</identifier><identifier>PMID: 29688840</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Acquired immune deficiency syndrome ; Aging ; AIDS ; Antiretroviral drugs ; Antiretroviral therapy ; Brief Reports ; C-reactive protein ; CD3 antigen ; CD4 antigen ; CD45RA antigen ; CD57 antigen ; CD8 antigen ; Cytokines ; Cytomegalovirus ; Dentistry ; Deoxyribonucleic acid ; DNA ; Drug therapy ; Granulocytes ; HIV ; Hospitals ; Human immunodeficiency virus ; Immunological memory ; Infections ; Inflammation ; Interferon ; Lymphocytes ; Lymphocytes T ; Medicine ; Memory cells ; Neutrophils ; Patients ; Persistent infection ; Phenotypes ; Ribonucleic acid ; RNA ; Tuberculosis ; Virology</subject><ispartof>Viral immunology, 2018-07, Vol.31 (6), p.472-479</ispartof><rights>2018, Mary Ann Liebert, Inc.</rights><rights>(©) Copyright 2018, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-b9547014c19ed1f52d91981de734945c376686db27e8ca1d60e0d6a55a2505343</citedby><cites>FETCH-LOGICAL-c404t-b9547014c19ed1f52d91981de734945c376686db27e8ca1d60e0d6a55a2505343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29688840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ariyanto, Ibnu A.</creatorcontrib><creatorcontrib>Estiasari, Riwanti</creatorcontrib><creatorcontrib>Waters, Shelley</creatorcontrib><creatorcontrib>Wulandari, Endah A.T.</creatorcontrib><creatorcontrib>Fernandez, Sonia</creatorcontrib><creatorcontrib>Lee, Silvia</creatorcontrib><creatorcontrib>Price, Patricia</creatorcontrib><title>Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy</title><title>Viral immunology</title><addtitle>Viral Immunol</addtitle><description>Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, and levels of CMV-reactive antibody to assess the persistent burden of CMV in a longitudinal study of 78 young adult patients beginning ART in Jakarta, Indonesia, with <200 CD4 T cells/
μ
L. CMV antibodies, inflammatory markers (C-reactive protein [CRP], soluble interferon-
α
/
β
receptor) and T cell phenotypes were assessed before ART (V0) and after 1, 3, 6, and 12 months (V1–V12). CMV DNA was detected in 41 patients (52%) at V0, irrespective of CD4 T cell counts, gender, age, or plasma HIV RNA. CMV DNA+ patients had higher levels of antibody reactive with CMV Immediate Early 1 (IE-1) at V0 and V12 (
p
= 0.04), and with CMV lysate at V12 (
p
= 0.01). Detectable CMV DNA did not align with inflammatory markers, but associated with lower CD4/CD8 ratios until V3. CMV antibody levels correlated inversely with proportions of naive CD4 and CD8 T cells, and directly with proportions of CD57
+
and activated memory T cells (CD3
+
CD45RA
−
) after 3–12 months on ART. Overall, active CMV replication is common in HIV patients beginning ART in Indonesia and associates with low CD4/CD8 ratios. Elevated levels of CMV-reactive antibody measured on ART also mark a depletion of naive T cells, accumulation of memory T cells, and may be a stable metric of the burden of CMV.</description><subject>Acquired immune deficiency syndrome</subject><subject>Aging</subject><subject>AIDS</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral therapy</subject><subject>Brief Reports</subject><subject>C-reactive protein</subject><subject>CD3 antigen</subject><subject>CD4 antigen</subject><subject>CD45RA antigen</subject><subject>CD57 antigen</subject><subject>CD8 antigen</subject><subject>Cytokines</subject><subject>Cytomegalovirus</subject><subject>Dentistry</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug therapy</subject><subject>Granulocytes</subject><subject>HIV</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Immunological memory</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Interferon</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medicine</subject><subject>Memory cells</subject><subject>Neutrophils</subject><subject>Patients</subject><subject>Persistent infection</subject><subject>Phenotypes</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Tuberculosis</subject><subject>Virology</subject><issn>0882-8245</issn><issn>1557-8976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkTFr3DAUgEVpaK5px65F0KWLL0-2JMvjYdLmIJAMl0Ino7OeUwVbukrywQ3975W5tEOXThLSx8d7fIR8YLBmoJrro53WJTC1BmD8FVkxIepCNbV8TVagVFmokotL8jbGZwBQUlVvyGXZSKUUhxX5temTPSLVztAHDNHGhC7R9pT8hE969Ecb5ki3bsAMehfpZliudEdbHMdIraPf_eye6MbMY6K322_0QSebJZG2fprQ9Xb5dckGTGHx6ZHufmDQh9M7cjHoMeL7l_OKPH652bW3xd391227uSt6DjwV-0bwOq_XswYNG0RpGtYoZrCueMNFX9VSKmn2ZY2q18xIQDBSC6FLAaLi1RX5fPYegv85Y0zdZGOf59cO_Ry7EipoGGdsQT_9gz77Obg8XaakAhDARaaKM9UHH2PAoTsEO-lw6hh0S5cud-mWLt3SJfMfX6zzfkLzl_4TIgPVGVietXOjxT2G9B_tb7R9meE</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Ariyanto, Ibnu A.</creator><creator>Estiasari, Riwanti</creator><creator>Waters, Shelley</creator><creator>Wulandari, Endah A.T.</creator><creator>Fernandez, Sonia</creator><creator>Lee, Silvia</creator><creator>Price, Patricia</creator><general>Mary Ann Liebert, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180701</creationdate><title>Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy</title><author>Ariyanto, Ibnu A. ; Estiasari, Riwanti ; Waters, Shelley ; Wulandari, Endah A.T. ; Fernandez, Sonia ; Lee, Silvia ; Price, Patricia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-b9547014c19ed1f52d91981de734945c376686db27e8ca1d60e0d6a55a2505343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Aging</topic><topic>AIDS</topic><topic>Antiretroviral drugs</topic><topic>Antiretroviral therapy</topic><topic>Brief Reports</topic><topic>C-reactive protein</topic><topic>CD3 antigen</topic><topic>CD4 antigen</topic><topic>CD45RA antigen</topic><topic>CD57 antigen</topic><topic>CD8 antigen</topic><topic>Cytokines</topic><topic>Cytomegalovirus</topic><topic>Dentistry</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug therapy</topic><topic>Granulocytes</topic><topic>HIV</topic><topic>Hospitals</topic><topic>Human immunodeficiency virus</topic><topic>Immunological memory</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Interferon</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medicine</topic><topic>Memory cells</topic><topic>Neutrophils</topic><topic>Patients</topic><topic>Persistent infection</topic><topic>Phenotypes</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Tuberculosis</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ariyanto, Ibnu A.</creatorcontrib><creatorcontrib>Estiasari, Riwanti</creatorcontrib><creatorcontrib>Waters, Shelley</creatorcontrib><creatorcontrib>Wulandari, Endah A.T.</creatorcontrib><creatorcontrib>Fernandez, Sonia</creatorcontrib><creatorcontrib>Lee, Silvia</creatorcontrib><creatorcontrib>Price, Patricia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Viral immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ariyanto, Ibnu A.</au><au>Estiasari, Riwanti</au><au>Waters, Shelley</au><au>Wulandari, Endah A.T.</au><au>Fernandez, Sonia</au><au>Lee, Silvia</au><au>Price, Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy</atitle><jtitle>Viral immunology</jtitle><addtitle>Viral Immunol</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>31</volume><issue>6</issue><spage>472</spage><epage>479</epage><pages>472-479</pages><issn>0882-8245</issn><eissn>1557-8976</eissn><abstract>Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, and levels of CMV-reactive antibody to assess the persistent burden of CMV in a longitudinal study of 78 young adult patients beginning ART in Jakarta, Indonesia, with <200 CD4 T cells/
μ
L. CMV antibodies, inflammatory markers (C-reactive protein [CRP], soluble interferon-
α
/
β
receptor) and T cell phenotypes were assessed before ART (V0) and after 1, 3, 6, and 12 months (V1–V12). CMV DNA was detected in 41 patients (52%) at V0, irrespective of CD4 T cell counts, gender, age, or plasma HIV RNA. CMV DNA+ patients had higher levels of antibody reactive with CMV Immediate Early 1 (IE-1) at V0 and V12 (
p
= 0.04), and with CMV lysate at V12 (
p
= 0.01). Detectable CMV DNA did not align with inflammatory markers, but associated with lower CD4/CD8 ratios until V3. CMV antibody levels correlated inversely with proportions of naive CD4 and CD8 T cells, and directly with proportions of CD57
+
and activated memory T cells (CD3
+
CD45RA
−
) after 3–12 months on ART. Overall, active CMV replication is common in HIV patients beginning ART in Indonesia and associates with low CD4/CD8 ratios. Elevated levels of CMV-reactive antibody measured on ART also mark a depletion of naive T cells, accumulation of memory T cells, and may be a stable metric of the burden of CMV.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>29688840</pmid><doi>10.1089/vim.2018.0014</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0882-8245 |
| ispartof | Viral immunology, 2018-07, Vol.31 (6), p.472-479 |
| issn | 0882-8245 1557-8976 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2030914114 |
| source | Alma/SFX Local Collection |
| subjects | Acquired immune deficiency syndrome Aging AIDS Antiretroviral drugs Antiretroviral therapy Brief Reports C-reactive protein CD3 antigen CD4 antigen CD45RA antigen CD57 antigen CD8 antigen Cytokines Cytomegalovirus Dentistry Deoxyribonucleic acid DNA Drug therapy Granulocytes HIV Hospitals Human immunodeficiency virus Immunological memory Infections Inflammation Interferon Lymphocytes Lymphocytes T Medicine Memory cells Neutrophils Patients Persistent infection Phenotypes Ribonucleic acid RNA Tuberculosis Virology |
| title | Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy |
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