Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy

Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy

Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, and levels of CMV-reactive antibody to assess the persiste...

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Veröffentlicht in:Viral immunology 2018-07, Vol.31 (6), p.472-479
Hauptverfasser: Ariyanto, Ibnu A., Estiasari, Riwanti, Waters, Shelley, Wulandari, Endah A.T., Fernandez, Sonia, Lee, Silvia, Price, Patricia
Format: Artikel
Sprache:eng
Schlagworte:
Acquired immune deficiency syndrome
Aging
AIDS
Antiretroviral drugs
Antiretroviral therapy
Brief Reports
C-reactive protein
CD3 antigen
CD4 antigen
CD45RA antigen
CD57 antigen
CD8 antigen
Cytokines
Cytomegalovirus
Dentistry
Deoxyribonucleic acid
DNA
Drug therapy
Granulocytes
HIV
Hospitals
Human immunodeficiency virus
Immunological memory
Infections
Inflammation
Interferon
Lymphocytes
Lymphocytes T
Medicine
Memory cells
Neutrophils
Patients
Persistent infection
Phenotypes
Ribonucleic acid
RNA
Tuberculosis
Virology
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Zusammenfassung:Altered T cell profiles have been linked with metrics of persistent cytomegalovirus (CMV) infections in healthy aging and older HIV patients stable on antiretroviral therapy (ART). In this study, we use CMV DNA to identify active infections, and levels of CMV-reactive antibody to assess the persistent burden of CMV in a longitudinal study of 78 young adult patients beginning ART in Jakarta, Indonesia, with
ISSN:0882-8245
1557-8976
DOI:10.1089/vim.2018.0014