Urinary steroid profiling by gas chromatography mass spectrometry: Early features of malignancy in patients with adrenal incidentalomas

Urinary steroid profiling by gas chromatography mass spectrometry: Early features of malignancy in patients with adrenal incidentalomas

•Urinary steroids are studied with GC–MS after surgery in patients with adrenocortical adenomas.•Patients with ACA + malignant potential had a sensitivity and specificity of major biomarkers of ACC.•Obtained data supports the hypothesis of a possible transformation of ACA into ACC.

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Bibliographische Detailangaben
Veröffentlicht in:Steroids 2018-07, Vol.135, p.31-35
Hauptverfasser: Shafigullina, Z.R., Velikanova, L.I., Vorokhobina, N.V., Shustov, S.B., Lisitsin, A.A., Malevanaia, E.V., Buinova, M.O., Bessonova, E.A., Kirsanov, D.O.
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal Gland Neoplasms - urine
Adult
Biomarkers, Tumor - urine
Case-Control Studies
Female
Gas Chromatography-Mass Spectrometry
Humans
Male
Middle Aged
Steroids - urine
Time Factors
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Beschreibung
Zusammenfassung:•Urinary steroids are studied with GC–MS after surgery in patients with adrenocortical adenomas.•Patients with ACA + malignant potential had a sensitivity and specificity of major biomarkers of ACC.•Obtained data supports the hypothesis of a possible transformation of ACA into ACC.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2018.04.006