Hydrogen sulfide is a novel mediator of lipopolysaccharide‐induced inflammation in the mouse

ABSTRACTHydrogen sulfide (H2S) is synthesized in the body from l‐cysteine by several enzymes including cystathionine‐γ‐lyase (CSE). To date, there is little information about the potential role of H2S in inflammation. We have now investigated the part played by H2S in endotoxin‐induced inflammation...

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Veröffentlicht in:	The FASEB journal 2005-07, Vol.19 (9), p.1196-1198
Hauptverfasser:	Li, Ling, Bhatia, Madhav, Zhu, Yi Zhun, Zhu, Yi Chun, Ramnath, Raina Devi, Wang, Zhong Jing, Anuar, Farhana Binte Mohammed, Whiteman, Matthew, Salto‐Tellez, Manuel, Moore, Philip K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - pharmacology Animals cystathionine‐γ‐lyase Escherichia coli Extracellular Signal-Regulated MAP Kinases - metabolism Glycine - analogs & derivatives Glycine - pharmacology H2S Hydrogen Sulfide - blood Hydrogen Sulfide - toxicity Inflammation - blood Inflammation - chemically induced Lipopolysaccharides - toxicity Lyases - genetics Male Mice p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation RNA, Messenger - analysis Shock, Septic - blood Sulfides - pharmacology
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Zusammenfassung:	ABSTRACTHydrogen sulfide (H2S) is synthesized in the body from l‐cysteine by several enzymes including cystathionine‐γ‐lyase (CSE). To date, there is little information about the potential role of H2S in inflammation. We have now investigated the part played by H2S in endotoxin‐induced inflammation in the mouse. E. coli lipopolysaccharide (LPS) administration produced a dose (10 and 20 mg/kg ip)‐ and time (6 and 24 h)‐dependent increase in plasma H2S concentration. LPS (10 mg/kg ip, 6 h) increased plasma H2S concentration from 34.1 ± 0.7 µM to 40.9 ± 0.6 µM (n=6, P
ISSN:	0892-6638 1530-6860
DOI:	10.1096/fj.04-3583fje