Electrophysiological measurements reveal that a succinyl linker enhances performance of the synthetic chloride channel SCMTR

Four variants of a synthetic chloride anion channel composed of dialkyamines linked to a heptapeptide have been studied in different lipid and polymer membranes using electrophysiological techniques. For the first time, the values of conductance states, voltage gating properties, and qualitative state transition frequency were measured in different lipid systems. Novel electrophysiological measurements reveal the values of conductance states, voltage gating properties and qualitative activity of a synthetic chloride channel.