Urinary angiotensinogen excretion in Australian Indigenous and non-Indigenous pregnant women

•Non-Indigenous women: uAGT increases in pregnancy and with gestational age.•Indigenous pregnant women: uAGT stable but lower than non-Indigenous women.•Non-Indigenous women with pregnancy complications have reduced uAGT/creatinine.•Reduced uAGT excretion may indicate renal dysfunction/pregnancy complications. The intrarenal renin-angiotensin system (iRAS) is implicated in the pathogenesis of hypertension, chronic kidney disease and diabetic nephropathy. Urinary angiotensinogen (uAGT) levels reflect the activity of the iRAS and are altered in women with preeclampsia. Since Indigenous Australians suffer high rates and early onset of renal disease, we hypothesised that Indigenous Australian pregnant women, like non-Indigenous women with pregnancy complications, would have altered uAGT levels. The excretion of RAS proteins was measured in non-Indigenous and Indigenous Australian women with uncomplicated or complicated pregnancies (preeclampsia, diabetes/gestational diabetes, proteinuria/albuminuria, hypertension, small/large for gestational age, preterm birth), and in non-pregnant non-Indigenous women. Non-Indigenous pregnant women with uncomplicated pregnancies, had higher uAGT/creatinine levels than non-Indigenous non-pregnant women (P