The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model

The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model

Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparing its biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors, in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal r...

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Veröffentlicht in:Acta medica Okayama 2008-12, Vol.62 (6), p.403-409
Hauptverfasser: Kilciksiz, Sevil, Demirel, Can, Erdal, Nurten, Gürgül, Serkan, Tamer, Lulufer, Ayaz, Lokman, Ors, Yasemin
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcysteine - pharmacology
Amifostine - pharmacology
Animals
Biomarkers - blood
Female
Free Radical Scavengers - pharmacology
Glutathione - blood
Liver - metabolism
Liver - radiation effects
Malondialdehyde - blood
Oxidative Stress - drug effects
Oxidative Stress - radiation effects
Peroxidase - blood
Radiation Dosage
Radiation Injuries, Experimental - drug therapy
Radiation Injuries, Experimental - metabolism
Radiation-Protective Agents - pharmacology
Rats
Rats, Wistar
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Zusammenfassung:Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparing its biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors, in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and equally into 4 groups:Control (C), Radiation (R), R+NAC (received irradiation and 1,000 mg/kg NAC) and R+WR-2721 (received irradiation and 200 mg/kg WR-2721) rats. Liver tissues and blood samples were harvested and utilized for reduced glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) detection. Serum and tissue GSH levels of R rats decreased compared to those of other groups (p
ISSN:0386-300X