When Sirtuins and NF- mu B Collide
Both the sirtuins and certain transcription factors of the NF- Kappa B/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF- Kappa B-dependent gene expression, thus unveiling a potential link betwe...
Gespeichert in:
| Veröffentlicht in: | Cell 2009-01, Vol.136 (1), p.19-21 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | Both the sirtuins and certain transcription factors of the NF- Kappa B/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF- Kappa B-dependent gene expression, thus unveiling a potential link between inflammation, aging, and metabolism. |
|---|---|
| ISSN: | 0092-8674 1097-4172 |
| DOI: | 10.1016/j.cell.2008.12.034 |