Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

Alzheimer's disease (AD) is characterized by the presence of tau filaments in the brain whose structure was recently solved. The formation of AD filaments is routinely modeled in vitro by mixing tau with heparin. This study shows that heparin-induced tau filaments are markedly different from th...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018, Vol.54 (36), p.4573-4576
Hauptverfasser:	Fichou, Yann, Vigers, Michael, Goring, Andrew K, Eschmann, Neil A, Han, Songi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Alzheimer's disease Amino Acid Sequence Amyloid - chemistry Amyloid - metabolism Brain Filaments Heparin - chemistry Heparin - metabolism Humans Membrane Proteins - chemistry Membrane Proteins - metabolism Molecular Structure Peptide Fragments - chemistry Peptide Fragments - metabolism Protein Aggregation, Pathological - metabolism Protein Binding Protein Multimerization - drug effects Protein Structure, Quaternary - drug effects Pyrrolidines - chemistry Spin Labels Thiosulfonic Acids - chemistry
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Beschreibung
Zusammenfassung:	Alzheimer's disease (AD) is characterized by the presence of tau filaments in the brain whose structure was recently solved. The formation of AD filaments is routinely modeled in vitro by mixing tau with heparin. This study shows that heparin-induced tau filaments are markedly different from the AD filaments and are highly heterogeneous.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c8cc01355a