Hepatitis D infection in Brazil: Prevalence and geographical distribution of anti‐Delta antibody
In Brazil, the Amazon Basin is endemic for hepatitis D virus (HDV) infection; however, studies in other regions of the country are scarce. This study aims to map the seroepidemiological situation of anti‐Delta antibodies in chronic hepatitis B carriers in all five Brazilian geographic regions. Serum...
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| Veröffentlicht in: | Journal of medical virology 2018-08, Vol.90 (8), p.1358-1363 |
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| creator | Lago, Barbara V. Mello, Francisco C. A. Barros, Tairine M. Mello, Vinicius M. Villar, Livia M. Lewis‐Ximenez, Lia L. Pardini, Maria Inês M. C. Lampe, Elisabeth |
| description | In Brazil, the Amazon Basin is endemic for hepatitis D virus (HDV) infection; however, studies in other regions of the country are scarce. This study aims to map the seroepidemiological situation of anti‐Delta antibodies in chronic hepatitis B carriers in all five Brazilian geographic regions. Serum samples from 1240 HBsAg positive individuals (55.4% men; mean age 43.1 ± 13.4 years) from 24 of 26 Brazilian states were tested for the presence of anti‐Delta antibodies using a commercial immunoassay. Anti‐Delta antibodies were detected in 40 samples (3.2%; 52.5% female; mean age of 38.1 ± 13.8 years). Age less than 20 years was significantly associated with anti‐HDV positivity (P |
| doi_str_mv | 10.1002/jmv.25196 |
| format | Article |
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A. ; Barros, Tairine M. ; Mello, Vinicius M. ; Villar, Livia M. ; Lewis‐Ximenez, Lia L. ; Pardini, Maria Inês M. C. ; Lampe, Elisabeth</creator><creatorcontrib>Lago, Barbara V. ; Mello, Francisco C. A. ; Barros, Tairine M. ; Mello, Vinicius M. ; Villar, Livia M. ; Lewis‐Ximenez, Lia L. ; Pardini, Maria Inês M. C. ; Lampe, Elisabeth ; Brazilian Hepatitis B Research Group ; on behalf of The Brazilian Hepatitis B Research Group</creatorcontrib><description>In Brazil, the Amazon Basin is endemic for hepatitis D virus (HDV) infection; however, studies in other regions of the country are scarce. This study aims to map the seroepidemiological situation of anti‐Delta antibodies in chronic hepatitis B carriers in all five Brazilian geographic regions. Serum samples from 1240 HBsAg positive individuals (55.4% men; mean age 43.1 ± 13.4 years) from 24 of 26 Brazilian states were tested for the presence of anti‐Delta antibodies using a commercial immunoassay. Anti‐Delta antibodies were detected in 40 samples (3.2%; 52.5% female; mean age of 38.1 ± 13.8 years). Age less than 20 years was significantly associated with anti‐HDV positivity (P < 0.001). The distribution of anti‐Delta differed markedly in the diverse regions of the country. The highest prevalence of anti‐HDV was found in the North (8.5%; P < 0.001), followed by Central West (2.5%), Southeast (1.7%), Northeast (0.8%), and South (0.0%). Anti‐Delta antibodies were detected in 12 states, but more than 60% of the positive cases were observed in two states, Amazonas and Acre, located in the western portion of the Amazon region. The overall HDV prevalence of 3.2% emphasizes that HDV is far from being a disease under control in Brazil. Despite the low HDV prevalence in non‐endemic regions, this infection persists as a major concern in two states (Acre and Amazonas) in the north of the country, indicating that a continuous epidemiological surveillance program should be implemented in all Brazilian regions.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.25196</identifier><identifier>PMID: 29663457</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Age ; Antibodies ; Brazil ; Disease control ; Epidemiology ; Geographical distribution ; HDV ; Hepatitis ; Hepatitis B ; Hepatitis B surface antigen ; Immunoassay ; Immunoglobulins ; Infections ; River basins ; Seroepidemiology ; Virology ; Viruses</subject><ispartof>Journal of medical virology, 2018-08, Vol.90 (8), p.1358-1363</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-6dbc787822c697619f73947c85401b382a8197d3d23f8d4594d43a68b4cbe3043</citedby><cites>FETCH-LOGICAL-c3536-6dbc787822c697619f73947c85401b382a8197d3d23f8d4594d43a68b4cbe3043</cites><orcidid>0000-0003-4561-4332 ; 0000-0002-9173-6309</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.25196$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.25196$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29663457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lago, Barbara V.</creatorcontrib><creatorcontrib>Mello, Francisco C. A.</creatorcontrib><creatorcontrib>Barros, Tairine M.</creatorcontrib><creatorcontrib>Mello, Vinicius M.</creatorcontrib><creatorcontrib>Villar, Livia M.</creatorcontrib><creatorcontrib>Lewis‐Ximenez, Lia L.</creatorcontrib><creatorcontrib>Pardini, Maria Inês M. C.</creatorcontrib><creatorcontrib>Lampe, Elisabeth</creatorcontrib><creatorcontrib>Brazilian Hepatitis B Research Group</creatorcontrib><creatorcontrib>on behalf of The Brazilian Hepatitis B Research Group</creatorcontrib><title>Hepatitis D infection in Brazil: Prevalence and geographical distribution of anti‐Delta antibody</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>In Brazil, the Amazon Basin is endemic for hepatitis D virus (HDV) infection; however, studies in other regions of the country are scarce. This study aims to map the seroepidemiological situation of anti‐Delta antibodies in chronic hepatitis B carriers in all five Brazilian geographic regions. Serum samples from 1240 HBsAg positive individuals (55.4% men; mean age 43.1 ± 13.4 years) from 24 of 26 Brazilian states were tested for the presence of anti‐Delta antibodies using a commercial immunoassay. Anti‐Delta antibodies were detected in 40 samples (3.2%; 52.5% female; mean age of 38.1 ± 13.8 years). Age less than 20 years was significantly associated with anti‐HDV positivity (P < 0.001). The distribution of anti‐Delta differed markedly in the diverse regions of the country. The highest prevalence of anti‐HDV was found in the North (8.5%; P < 0.001), followed by Central West (2.5%), Southeast (1.7%), Northeast (0.8%), and South (0.0%). Anti‐Delta antibodies were detected in 12 states, but more than 60% of the positive cases were observed in two states, Amazonas and Acre, located in the western portion of the Amazon region. The overall HDV prevalence of 3.2% emphasizes that HDV is far from being a disease under control in Brazil. Despite the low HDV prevalence in non‐endemic regions, this infection persists as a major concern in two states (Acre and Amazonas) in the north of the country, indicating that a continuous epidemiological surveillance program should be implemented in all Brazilian regions.</description><subject>Age</subject><subject>Antibodies</subject><subject>Brazil</subject><subject>Disease control</subject><subject>Epidemiology</subject><subject>Geographical distribution</subject><subject>HDV</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B surface antigen</subject><subject>Immunoassay</subject><subject>Immunoglobulins</subject><subject>Infections</subject><subject>River basins</subject><subject>Seroepidemiology</subject><subject>Virology</subject><subject>Viruses</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp10LtOwzAUBmALgWi5DLwAisQCQ6lv8YWNe0FFMABr5NhOcZUmxU5AZeIReEaeBLcFBiSm4yN9_nX0A7CD4CGCEPfHk5dDnCLJVkAXQcl6EnK0CroQUdZjDKUdsBHCGEIoJMbroIMlY4SmvAvygZ2qxjUuJGeJqwqrG1dX8ZWcePXmyqPkztsXVdpK20RVJhnZeuTV9MlpVSbGhca7vF38qYsIGvf5_nFmy0Ytlrw2sy2wVqgy2O3vuQkeLs7vTwe94e3l1enxsKdJSuKdJtdccIGxZpIzJAtOJOVapBSinAisBJLcEINJIQxNJTWUKCZyqnNLICWbYH-ZO_X1c2tDk01c0LYsVWXrNmQYYkYRI2JO9_7Qcd36Kl4XVcoRJ1TiqA6WSvs6BG-LbOrdRPlZhmA2Lz6LxWeL4qPd_U5s84k1v_Kn6Qj6S_DqSjv7Pym7vnlcRn4BJDaMbg</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Lago, Barbara V.</creator><creator>Mello, Francisco C. 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A. ; Barros, Tairine M. ; Mello, Vinicius M. ; Villar, Livia M. ; Lewis‐Ximenez, Lia L. ; Pardini, Maria Inês M. C. ; Lampe, Elisabeth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-6dbc787822c697619f73947c85401b382a8197d3d23f8d4594d43a68b4cbe3043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Antibodies</topic><topic>Brazil</topic><topic>Disease control</topic><topic>Epidemiology</topic><topic>Geographical distribution</topic><topic>HDV</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B surface antigen</topic><topic>Immunoassay</topic><topic>Immunoglobulins</topic><topic>Infections</topic><topic>River basins</topic><topic>Seroepidemiology</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lago, Barbara V.</creatorcontrib><creatorcontrib>Mello, Francisco C. 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C.</creatorcontrib><creatorcontrib>Lampe, Elisabeth</creatorcontrib><creatorcontrib>Brazilian Hepatitis B Research Group</creatorcontrib><creatorcontrib>on behalf of The Brazilian Hepatitis B Research Group</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lago, Barbara V.</au><au>Mello, Francisco C. A.</au><au>Barros, Tairine M.</au><au>Mello, Vinicius M.</au><au>Villar, Livia M.</au><au>Lewis‐Ximenez, Lia L.</au><au>Pardini, Maria Inês M. C.</au><au>Lampe, Elisabeth</au><aucorp>Brazilian Hepatitis B Research Group</aucorp><aucorp>on behalf of The Brazilian Hepatitis B Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis D infection in Brazil: Prevalence and geographical distribution of anti‐Delta antibody</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2018-08</date><risdate>2018</risdate><volume>90</volume><issue>8</issue><spage>1358</spage><epage>1363</epage><pages>1358-1363</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>In Brazil, the Amazon Basin is endemic for hepatitis D virus (HDV) infection; however, studies in other regions of the country are scarce. This study aims to map the seroepidemiological situation of anti‐Delta antibodies in chronic hepatitis B carriers in all five Brazilian geographic regions. Serum samples from 1240 HBsAg positive individuals (55.4% men; mean age 43.1 ± 13.4 years) from 24 of 26 Brazilian states were tested for the presence of anti‐Delta antibodies using a commercial immunoassay. Anti‐Delta antibodies were detected in 40 samples (3.2%; 52.5% female; mean age of 38.1 ± 13.8 years). Age less than 20 years was significantly associated with anti‐HDV positivity (P < 0.001). The distribution of anti‐Delta differed markedly in the diverse regions of the country. The highest prevalence of anti‐HDV was found in the North (8.5%; P < 0.001), followed by Central West (2.5%), Southeast (1.7%), Northeast (0.8%), and South (0.0%). Anti‐Delta antibodies were detected in 12 states, but more than 60% of the positive cases were observed in two states, Amazonas and Acre, located in the western portion of the Amazon region. The overall HDV prevalence of 3.2% emphasizes that HDV is far from being a disease under control in Brazil. Despite the low HDV prevalence in non‐endemic regions, this infection persists as a major concern in two states (Acre and Amazonas) in the north of the country, indicating that a continuous epidemiological surveillance program should be implemented in all Brazilian regions.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29663457</pmid><doi>10.1002/jmv.25196</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4561-4332</orcidid><orcidid>https://orcid.org/0000-0002-9173-6309</orcidid></addata></record> |
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| subjects | Age Antibodies Brazil Disease control Epidemiology Geographical distribution HDV Hepatitis Hepatitis B Hepatitis B surface antigen Immunoassay Immunoglobulins Infections River basins Seroepidemiology Virology Viruses |
| title | Hepatitis D infection in Brazil: Prevalence and geographical distribution of anti‐Delta antibody |
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