Effects of Psoralea corylifolia on the cAMP-responsive element modulator (CREM) expression and spermatogenesis in rats

Psoralea corylifolia (PC) is a medicinal herb used to improve male reproductive function in Korean traditional medicine. It has been used for treatment of male infertility including sexual dysfunction by improving kidney function. To investigate the effect of PC on spermatogenesis, the cAMP-responsi...

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Veröffentlicht in:	Journal of ethnopharmacology 2008-05, Vol.117 (3), p.503-506
Hauptverfasser:	Yang, Woong Mo, Chang, Mun Seog, Park, Seong Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Antineoplastic Agents, Alkylating - pharmacology Biological and medical sciences Blotting, Western Body Weight - drug effects cAMP-responsive element modulator cAMP-responsive element modulator (CREM) Cullen corylifolium cyclic AMP Cyclic AMP Response Element Modulator - biosynthesis Cyclic AMP Response Element Modulator - genetics Cyclophosphamide - pharmacology DNA, Complementary - biosynthesis DNA, Complementary - genetics General pharmacology herbal medicines Male male fertility Male reproductive function Medical sciences medicinal plants medicinal properties messenger RNA Organ Size - drug effects Oriental traditional medicine Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Psoralea Psoralea - chemistry Psoralea corylifolia Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Sperm Count Sperm Motility - drug effects Spermatogenesis Spermatogenesis - drug effects spermatozoa testes Testis - anatomy & histology Testis - drug effects
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Zusammenfassung:	Psoralea corylifolia (PC) is a medicinal herb used to improve male reproductive function in Korean traditional medicine. It has been used for treatment of male infertility including sexual dysfunction by improving kidney function. To investigate the effect of PC on spermatogenesis, the cAMP-responsive element modulator (CREM) in rat testes was evaluated using sperm analysis, the reverse-transcription polymerase chain reaction, and Western blot analysis. PC was administered to 10-week-old male Wistar rats for 56 consecutive days, the sperm formation period of the rat. The PC-treated rats had increased sperm counts with enhanced levels of CREM messenger RNA and protein, suggesting that PC induces spermatogenesis via CREM activation in rat testes.
ISSN:	0378-8741 1872-7573
DOI:	10.1016/j.jep.2008.02.016