Total choline quantification measured by 1H MR spectroscopy as early predictor of response after neoadjuvant treatment for locally advanced breast cancer: The impact of immunohistochemical status

Background Validation of new biomarkers is essential for the early evaluation of neoadjuvant treatments. Purpose To determine whether measurements of total choline (tCho) by 1H spectroscopy could predict morphological or pathological complete response (pCR) of neoadjuvant treatment and whether breas...

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Veröffentlicht in:	Journal of magnetic resonance imaging 2018-10, Vol.48 (4), p.982-993
Hauptverfasser:	Drisis, Stylianos, Flamen, Patrick, Ignatiadis, Michael, Metens, Thierry, Chao, Shih‐Li, Chintinne, Marie, Lemort, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracycline Biomarkers Breast cancer Cancer Cancer therapies Chemotherapy Choline Diagnostic systems estrogen receptor Field strength Magnetic resonance imaging Magnetic resonance spectroscopy Medical imaging Morphology MRS neoadjuvant chemotherapy Parameter modification Patients Population (statistical) Population studies Regression analysis Spectroscopy Spectrum analysis Statistical analysis Statistical tests Subgroups Taxanes triple negative breast cancer Tumors Variance analysis
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