Potential role of extracellular vesicle–mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy
[...]we consider that H pylori components are required to invade the body to induce an immune reaction against H pylori. [...]even if H pylori components invade the body, they would be rapidly degraded by enzymes. [...]we used EVs from patients' sera; however, the EVs did not successfully induc...
Gespeichert in:
| Veröffentlicht in: | Journal of allergy and clinical immunology 2018-08, Vol.142 (2), p.672-676.e12 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 676.e12 |
|---|---|
| container_issue | 2 |
| container_start_page | 672 |
| container_title | Journal of allergy and clinical immunology |
| container_volume | 142 |
| creator | Ito, Takamasa Shiromizu, Takashi Ohnishi, Shunsuke Suzuki, Shotaro Mabe, Katsuhiro Hasegawa, Akito Ujiie, Hideyuki Fujita, Yasuyuki Sato, Yuichi Terai, Shuji Kato, Mototsugu Asaka, Masahiro Tomonaga, Takeshi Shimizu, Hiroshi Abe, Riichiro |
| description | [...]we consider that H pylori components are required to invade the body to induce an immune reaction against H pylori. [...]even if H pylori components invade the body, they would be rapidly degraded by enzymes. [...]we used EVs from patients' sera; however, the EVs did not successfully induce an immune reaction, as determined by using flow cytometric analysis of CD154+ H pylori–specific T cells. [...]it would be possible to reattempt or resume H pylori eradication therapy when skin eruptions develop because drug eruptions could be ruled out. [...]H pylori components in EVs can induce skin manifestations during antibiotic treatment. |
| doi_str_mv | 10.1016/j.jaci.2018.02.046 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2025319041</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S009167491830513X</els_id><sourcerecordid>2082047602</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-ec71d5a546b054d16f497d82481b8044fcc6d0c438f9266d7ddae4fcae3ace0c3</originalsourceid><addsrcrecordid>eNp9kTFv1TAUhS1ERV8Lf4ABWWJhSXrtOE4isaAKWqRKZYDZ8rNvWkd5cbCdp2ZjZuUf9pfgp1cYGJisa33n6N5zCHnNoGTA5MVQDtq4kgNrS-AlCPmMbBh0TSFbXj8nG4COFbIR3Sk5i3GAPFdt94Kc8k7WFWPNhvz84hNOyemRBj8i9T3FhxS0wXFcRh3oHqMzIz7--LVD63RCS3Xm73Cic8CYtTo5P1E30WscnfFbbRIGOq-jD47erzOGTEWX3N6lldoluOmOYtDWmaM03edpXl-Sk16PEV89vefk26ePXy-vi5vbq8-XH24KI2pIBZqG2VrXQm6hFpbJXnSNbblo2bYFIXpjpAUjqrbvuJS2sVZj_tVY5avAVOfk3dF3Dv77gjGpnYuHe_WEfomKA8_hdCBYRt_-gw5-CVPeLlMtB9FI4JniR8oEH2PAXs3B7XRYFQN1aEoN6tCUOjSlgKvcVBa9ebJetjnZv5I_1WTg_RHAnMXeYVDROJxMbiGgScp69z__36H6qc4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2082047602</pqid></control><display><type>article</type><title>Potential role of extracellular vesicle–mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Ito, Takamasa ; Shiromizu, Takashi ; Ohnishi, Shunsuke ; Suzuki, Shotaro ; Mabe, Katsuhiro ; Hasegawa, Akito ; Ujiie, Hideyuki ; Fujita, Yasuyuki ; Sato, Yuichi ; Terai, Shuji ; Kato, Mototsugu ; Asaka, Masahiro ; Tomonaga, Takeshi ; Shimizu, Hiroshi ; Abe, Riichiro</creator><creatorcontrib>Ito, Takamasa ; Shiromizu, Takashi ; Ohnishi, Shunsuke ; Suzuki, Shotaro ; Mabe, Katsuhiro ; Hasegawa, Akito ; Ujiie, Hideyuki ; Fujita, Yasuyuki ; Sato, Yuichi ; Terai, Shuji ; Kato, Mototsugu ; Asaka, Masahiro ; Tomonaga, Takeshi ; Shimizu, Hiroshi ; Abe, Riichiro</creatorcontrib><description>[...]we consider that H pylori components are required to invade the body to induce an immune reaction against H pylori. [...]even if H pylori components invade the body, they would be rapidly degraded by enzymes. [...]we used EVs from patients' sera; however, the EVs did not successfully induce an immune reaction, as determined by using flow cytometric analysis of CD154+ H pylori–specific T cells. [...]it would be possible to reattempt or resume H pylori eradication therapy when skin eruptions develop because drug eruptions could be ruled out. [...]H pylori components in EVs can induce skin manifestations during antibiotic treatment.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2018.02.046</identifier><identifier>PMID: 29653117</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Antigen Presentation ; Antigens, Bacterial - immunology ; Cells, Cultured ; Cytokines ; Dehydrogenases ; Dendritic Cells - immunology ; Deoxyribonucleic acid ; DNA ; DNA polymerase ; Drug Therapy, Combination ; Enzyme-Linked Immunospot Assay ; Extracellular Vesicles - immunology ; Female ; Gastric cancer ; Helicobacter Infections - complications ; Helicobacter Infections - drug therapy ; Helicobacter Infections - immunology ; Helicobacter pylori - physiology ; Humans ; Hypersensitivity ; Hypersensitivity - complications ; Hypersensitivity - immunology ; Interferon-gamma - metabolism ; Leukocytes, Mononuclear - immunology ; Lymphocytes ; Male ; Middle Aged ; Patients ; Proteins ; Proton Pump Inhibitors - therapeutic use ; Skin ; Skin - pathology ; Stomach Neoplasms - etiology ; Stomach Neoplasms - prevention & control</subject><ispartof>Journal of allergy and clinical immunology, 2018-08, Vol.142 (2), p.672-676.e12</ispartof><rights>2018 American Academy of Allergy, Asthma & Immunology</rights><rights>Copyright Elsevier Limited Aug 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-ec71d5a546b054d16f497d82481b8044fcc6d0c438f9266d7ddae4fcae3ace0c3</citedby><cites>FETCH-LOGICAL-c450t-ec71d5a546b054d16f497d82481b8044fcc6d0c438f9266d7ddae4fcae3ace0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2018.02.046$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29653117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Takamasa</creatorcontrib><creatorcontrib>Shiromizu, Takashi</creatorcontrib><creatorcontrib>Ohnishi, Shunsuke</creatorcontrib><creatorcontrib>Suzuki, Shotaro</creatorcontrib><creatorcontrib>Mabe, Katsuhiro</creatorcontrib><creatorcontrib>Hasegawa, Akito</creatorcontrib><creatorcontrib>Ujiie, Hideyuki</creatorcontrib><creatorcontrib>Fujita, Yasuyuki</creatorcontrib><creatorcontrib>Sato, Yuichi</creatorcontrib><creatorcontrib>Terai, Shuji</creatorcontrib><creatorcontrib>Kato, Mototsugu</creatorcontrib><creatorcontrib>Asaka, Masahiro</creatorcontrib><creatorcontrib>Tomonaga, Takeshi</creatorcontrib><creatorcontrib>Shimizu, Hiroshi</creatorcontrib><creatorcontrib>Abe, Riichiro</creatorcontrib><title>Potential role of extracellular vesicle–mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>[...]we consider that H pylori components are required to invade the body to induce an immune reaction against H pylori. [...]even if H pylori components invade the body, they would be rapidly degraded by enzymes. [...]we used EVs from patients' sera; however, the EVs did not successfully induce an immune reaction, as determined by using flow cytometric analysis of CD154+ H pylori–specific T cells. [...]it would be possible to reattempt or resume H pylori eradication therapy when skin eruptions develop because drug eruptions could be ruled out. [...]H pylori components in EVs can induce skin manifestations during antibiotic treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Antigen Presentation</subject><subject>Antigens, Bacterial - immunology</subject><subject>Cells, Cultured</subject><subject>Cytokines</subject><subject>Dehydrogenases</subject><subject>Dendritic Cells - immunology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA polymerase</subject><subject>Drug Therapy, Combination</subject><subject>Enzyme-Linked Immunospot Assay</subject><subject>Extracellular Vesicles - immunology</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - immunology</subject><subject>Helicobacter pylori - physiology</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Hypersensitivity - complications</subject><subject>Hypersensitivity - immunology</subject><subject>Interferon-gamma - metabolism</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Proteins</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><subject>Skin</subject><subject>Skin - pathology</subject><subject>Stomach Neoplasms - etiology</subject><subject>Stomach Neoplasms - prevention & control</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kTFv1TAUhS1ERV8Lf4ABWWJhSXrtOE4isaAKWqRKZYDZ8rNvWkd5cbCdp2ZjZuUf9pfgp1cYGJisa33n6N5zCHnNoGTA5MVQDtq4kgNrS-AlCPmMbBh0TSFbXj8nG4COFbIR3Sk5i3GAPFdt94Kc8k7WFWPNhvz84hNOyemRBj8i9T3FhxS0wXFcRh3oHqMzIz7--LVD63RCS3Xm73Cic8CYtTo5P1E30WscnfFbbRIGOq-jD47erzOGTEWX3N6lldoluOmOYtDWmaM03edpXl-Sk16PEV89vefk26ePXy-vi5vbq8-XH24KI2pIBZqG2VrXQm6hFpbJXnSNbblo2bYFIXpjpAUjqrbvuJS2sVZj_tVY5avAVOfk3dF3Dv77gjGpnYuHe_WEfomKA8_hdCBYRt_-gw5-CVPeLlMtB9FI4JniR8oEH2PAXs3B7XRYFQN1aEoN6tCUOjSlgKvcVBa9ebJetjnZv5I_1WTg_RHAnMXeYVDROJxMbiGgScp69z__36H6qc4</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Ito, Takamasa</creator><creator>Shiromizu, Takashi</creator><creator>Ohnishi, Shunsuke</creator><creator>Suzuki, Shotaro</creator><creator>Mabe, Katsuhiro</creator><creator>Hasegawa, Akito</creator><creator>Ujiie, Hideyuki</creator><creator>Fujita, Yasuyuki</creator><creator>Sato, Yuichi</creator><creator>Terai, Shuji</creator><creator>Kato, Mototsugu</creator><creator>Asaka, Masahiro</creator><creator>Tomonaga, Takeshi</creator><creator>Shimizu, Hiroshi</creator><creator>Abe, Riichiro</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201808</creationdate><title>Potential role of extracellular vesicle–mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy</title><author>Ito, Takamasa ; Shiromizu, Takashi ; Ohnishi, Shunsuke ; Suzuki, Shotaro ; Mabe, Katsuhiro ; Hasegawa, Akito ; Ujiie, Hideyuki ; Fujita, Yasuyuki ; Sato, Yuichi ; Terai, Shuji ; Kato, Mototsugu ; Asaka, Masahiro ; Tomonaga, Takeshi ; Shimizu, Hiroshi ; Abe, Riichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-ec71d5a546b054d16f497d82481b8044fcc6d0c438f9266d7ddae4fcae3ace0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Antigen Presentation</topic><topic>Antigens, Bacterial - immunology</topic><topic>Cells, Cultured</topic><topic>Cytokines</topic><topic>Dehydrogenases</topic><topic>Dendritic Cells - immunology</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA polymerase</topic><topic>Drug Therapy, Combination</topic><topic>Enzyme-Linked Immunospot Assay</topic><topic>Extracellular Vesicles - immunology</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter Infections - immunology</topic><topic>Helicobacter pylori - physiology</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Hypersensitivity - complications</topic><topic>Hypersensitivity - immunology</topic><topic>Interferon-gamma - metabolism</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Proteins</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Skin</topic><topic>Skin - pathology</topic><topic>Stomach Neoplasms - etiology</topic><topic>Stomach Neoplasms - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Takamasa</creatorcontrib><creatorcontrib>Shiromizu, Takashi</creatorcontrib><creatorcontrib>Ohnishi, Shunsuke</creatorcontrib><creatorcontrib>Suzuki, Shotaro</creatorcontrib><creatorcontrib>Mabe, Katsuhiro</creatorcontrib><creatorcontrib>Hasegawa, Akito</creatorcontrib><creatorcontrib>Ujiie, Hideyuki</creatorcontrib><creatorcontrib>Fujita, Yasuyuki</creatorcontrib><creatorcontrib>Sato, Yuichi</creatorcontrib><creatorcontrib>Terai, Shuji</creatorcontrib><creatorcontrib>Kato, Mototsugu</creatorcontrib><creatorcontrib>Asaka, Masahiro</creatorcontrib><creatorcontrib>Tomonaga, Takeshi</creatorcontrib><creatorcontrib>Shimizu, Hiroshi</creatorcontrib><creatorcontrib>Abe, Riichiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Takamasa</au><au>Shiromizu, Takashi</au><au>Ohnishi, Shunsuke</au><au>Suzuki, Shotaro</au><au>Mabe, Katsuhiro</au><au>Hasegawa, Akito</au><au>Ujiie, Hideyuki</au><au>Fujita, Yasuyuki</au><au>Sato, Yuichi</au><au>Terai, Shuji</au><au>Kato, Mototsugu</au><au>Asaka, Masahiro</au><au>Tomonaga, Takeshi</au><au>Shimizu, Hiroshi</au><au>Abe, Riichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential role of extracellular vesicle–mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2018-08</date><risdate>2018</risdate><volume>142</volume><issue>2</issue><spage>672</spage><epage>676.e12</epage><pages>672-676.e12</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>[...]we consider that H pylori components are required to invade the body to induce an immune reaction against H pylori. [...]even if H pylori components invade the body, they would be rapidly degraded by enzymes. [...]we used EVs from patients' sera; however, the EVs did not successfully induce an immune reaction, as determined by using flow cytometric analysis of CD154+ H pylori–specific T cells. [...]it would be possible to reattempt or resume H pylori eradication therapy when skin eruptions develop because drug eruptions could be ruled out. [...]H pylori components in EVs can induce skin manifestations during antibiotic treatment.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29653117</pmid><doi>10.1016/j.jaci.2018.02.046</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2018-08, Vol.142 (2), p.672-676.e12 |
| issn | 0091-6749 1097-6825 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2025319041 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged Anti-Bacterial Agents - therapeutic use Antibiotics Antigen Presentation Antigens, Bacterial - immunology Cells, Cultured Cytokines Dehydrogenases Dendritic Cells - immunology Deoxyribonucleic acid DNA DNA polymerase Drug Therapy, Combination Enzyme-Linked Immunospot Assay Extracellular Vesicles - immunology Female Gastric cancer Helicobacter Infections - complications Helicobacter Infections - drug therapy Helicobacter Infections - immunology Helicobacter pylori - physiology Humans Hypersensitivity Hypersensitivity - complications Hypersensitivity - immunology Interferon-gamma - metabolism Leukocytes, Mononuclear - immunology Lymphocytes Male Middle Aged Patients Proteins Proton Pump Inhibitors - therapeutic use Skin Skin - pathology Stomach Neoplasms - etiology Stomach Neoplasms - prevention & control |
| title | Potential role of extracellular vesicle–mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T03%3A51%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Potential%20role%20of%20extracellular%20vesicle%E2%80%93mediated%20antigen%20presentation%20in%20Helicobacter%20pylori%20hypersensitivity%20during%20eradication%20therapy&rft.jtitle=Journal%20of%20allergy%20and%20clinical%20immunology&rft.au=Ito,%20Takamasa&rft.date=2018-08&rft.volume=142&rft.issue=2&rft.spage=672&rft.epage=676.e12&rft.pages=672-676.e12&rft.issn=0091-6749&rft.eissn=1097-6825&rft_id=info:doi/10.1016/j.jaci.2018.02.046&rft_dat=%3Cproquest_cross%3E2082047602%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2082047602&rft_id=info:pmid/29653117&rft_els_id=S009167491830513X&rfr_iscdi=true |