Potential role of extracellular vesicle–mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy

[...]we consider that H pylori components are required to invade the body to induce an immune reaction against H pylori. [...]even if H pylori components invade the body, they would be rapidly degraded by enzymes. [...]we used EVs from patients' sera; however, the EVs did not successfully induce an immune reaction, as determined by using flow cytometric analysis of CD154+ H pylori–specific T cells. [...]it would be possible to reattempt or resume H pylori eradication therapy when skin eruptions develop because drug eruptions could be ruled out. [...]H pylori components in EVs can induce skin manifestations during antibiotic treatment.