Glycosylated piericidins from an endophytic streptomyces with cytotoxicity and antimicrobial activity

Two new glycosylated piericidins, glucopiericidinol A 3 ( 1 ) and 7-demethyl-glucopiericidin A ( 2 ), along with four known analogs were isolated from the culture broth of Streptomyces sp. KIB-H1083. The chemical structures of new compounds were elucidated by spectroscopic analyses. Their cytotoxicity on HL-60, SMMC-772, A-549, MCF-7, and SW480 cell lines, as well as antimicrobial activities was evaluated. The results showed that glucopiericidin A ( 4 ) has potent cytotoxicity against HL-60, SMMC-772, A-549, and MCF-7 cell lines with IC 50 values of 0.34, 0.65, 0.60, and 0.50 μ m , respectively. For the antimicrobial activity, piericidin A ( 6 ) showed most powerful inhibitory activities against Xanthomonas oryzae pv . oryzicola , and Penicillium decumbens .