Detection of human parvovirus B19 infection in the thymus of patients with thymic hyperplasia-associated myasthenia gravis

To investigate the association between myasthenia gravis (MG) and human parvovirus B19 (B19V) infection in the thymus. The presence of human B19V DNA and protein was assessed in 138 samples—including 68 thymic hyperplasias (39 with MG), 58 thymomas (23 with MG), and 12 normal thymus tissues—using a...

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Veröffentlicht in:	Clinical microbiology and infection 2019-01, Vol.25 (1), p.109.e7-109.e12
Hauptverfasser:	Gong, L., Li, Y., Li, X., Tu, Q., Mou, X., Wang, S., Wan, Y., Lu, Q., Wang, J., Zhang, W., Zhu, S., Han, X., Yao, L., Zhang, J., Huang, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Erythema Infectiosum - diagnosis Female Humans Immunohistochemistry inflammation Male Middle Aged myasthenia gravis Myasthenia Gravis - etiology Myasthenia Gravis - pathology Myasthenia Gravis - virology Parvovirus B19 thymic hyperplasia thymoma Thymoma - virology Thymus Gland - virology Thymus Hyperplasia - complications Thymus Hyperplasia - virology Young Adult
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Zusammenfassung:	To investigate the association between myasthenia gravis (MG) and human parvovirus B19 (B19V) infection in the thymus. The presence of human B19V DNA and protein was assessed in 138 samples—including 68 thymic hyperplasias (39 with MG), 58 thymomas (23 with MG), and 12 normal thymus tissues—using a nested polymerase chain reaction, immunohistochemistry, laser capture microdissection, and sequencing in a double-blinded manner. B19V DNA was detected mainly in thymic hyperplasia, and the positivity rate (41.18%, 28/68) was significantly higher than that in thymoma (3.45%, 2/58) (p
ISSN:	1198-743X 1469-0691
DOI:	10.1016/j.cmi.2018.03.036