MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activities

Here, we characterize the actions of MK-0767, a dual ligand of the nuclear receptors peroxisome proliferator-activated receptor (PPAR)α and PPARγ. In cell-based assays, MK-0767 produced potent activation of human PPARγ and PPARα with a γ:α potency ratio of ≈2. The dual agonist induced high affinity...

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Veröffentlicht in:Biochemical and biophysical research communications 2004-05, Vol.318 (2), p.323-328
Hauptverfasser: Doebber, Thomas W, Kelly, Linda J, Zhou, Gaochao, Meurer, Roger, Biswas, Chhabi, Li, Ying, Wu, Margaret S, Ippolito, Marc C, Chao, Yu-Sheng, Wang, Pei-Ran, Wright, Samuel D, Moller, David E, Berger, Joel P
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Sprache:eng
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Zusammenfassung:Here, we characterize the actions of MK-0767, a dual ligand of the nuclear receptors peroxisome proliferator-activated receptor (PPAR)α and PPARγ. In cell-based assays, MK-0767 produced potent activation of human PPARγ and PPARα with a γ:α potency ratio of ≈2. The dual agonist induced high affinity interactions of PPARα and PPARγ with the transcriptional coactivator CBP in vitro. In ob/ob mice, MK-0767 normalized hyperglycemia and hyperinsulinemia with equal or greater potency and efficacy than pioglitazone. Treatment of hamsters with MK-0767 produced substantial reductions in blood cholesterol and triglycerides. In dogs, MK-0767 reduced serum cholesterol levels with a potency more than 10-fold greater than simvastatin. The efficacies of MK-0767 and simvastatin were additive when given together. We conclude that MK-0767 is a potent dual PPARα/γ agonist with robust insulin sensitizing and hypolipidemic activities.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2004.04.032