Dispersion of multi-walled carbon nanotubes in [BMIM]PF6 for electrochemical sensing of acetaminophen

The influence of functionalized multi-walled carbon nanotubes (fMWCNT) in the presence of 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM]PF6) in different ratios was investigated on the acetaminophen (ACOP) electrochemical determination. The electrochemical behavior of the ACOP exhibited a pair of well-defined redox peaks, suggesting that the reversibility of ACOP was significantly improved in comparison to irreversible oxidation peak on bare GCE. The redox process was controlled by adsorption, involves two electrons and the value of apparent rate constant (ks) was equal to 14.7 s−1 ± 3.6 s−1. The analytical curves were obtained for concentrations of ACOP ranging from 0.3 to 3.0 μmol L−1. The values of the detection limit were calculated from SWV and found to be 6.73 × 10−8 mol L−1. The proposed electrochemical sensor exhibited good stability and reproducibility and was applied for ACOP determination in tablets (Tylenol® and Tylenol®DC) with satisfactory results. [Display omitted] •[BMIM]PF6 was used in the development of electrochemical sensor for ACOP.•Electrochemical effect of [BMIM]PF6 on oxidation of ACOP was investigated.•The current response from square-wave voltammograms is proportionally linear with the acetaminophen concentration.•Excellent stability and repeatability of the sensor proposed its good potential for practical applications.