hTERT mRNA expression in urine as a useful diagnostic tool in bladder cancer. Comparison with cytology and NMP22 BladderCheck Test
To study the relationship between quantitative mRNA determination (hTERT) in patients with bladder tumor, history of bladder tumor, and in subjects without a history of this neoplasia. A prospective randomized controlled study with 91 subjects included. The value of mRNA-hTERT was determined in 63 p...
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| Veröffentlicht in: | Actas urológicas españolas (English ed.) 2018-10, Vol.42 (8), p.524-530 |
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| container_title | Actas urológicas españolas (English ed.) |
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| creator | March-Villalba, J A Panach-Navarrete, J Herrero-Cervera, M J Aliño-Pellicer, S Martínez-Jabaloyas, J M |
| description | To study the relationship between quantitative mRNA determination (hTERT) in patients with bladder tumor, history of bladder tumor, and in subjects without a history of this neoplasia.
A prospective randomized controlled study with 91 subjects included. The value of mRNA-hTERT
was determined in 63 patients with a history or suspicion of bladder tumor and in 28 controls. Urine samples were sent for evaluation of the mRNA level (hTERT), the cytological study and the NMP22 result.
Differences were observed in mean hTERT
levels in each of the groups: tumor presence 21.33+/- 40.66, tumor history 2.16+/- 2.67, controls 0.9+/- 1, 75 (p |
| doi_str_mv | 10.1016/j.acuro.2018.02.002 |
| format | Article |
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A prospective randomized controlled study with 91 subjects included. The value of mRNA-hTERT
was determined in 63 patients with a history or suspicion of bladder tumor and in 28 controls. Urine samples were sent for evaluation of the mRNA level (hTERT), the cytological study and the NMP22 result.
Differences were observed in mean hTERT
levels in each of the groups: tumor presence 21.33+/- 40.66, tumor history 2.16+/- 2.67, controls 0.9+/- 1, 75 (p<0.001). In patients with tumor, there was no difference in mean hTERT
levels between the different grades and stages, although there was a tendency: low grade tumor 9.04+/- 16.95, high grade 28.95+/- 48.36 (p=.069), stage Ta 10.33+/- 19.39, T1 17.88+/- 27.14, T2 54.8+/- 74.05 (p=.056). In addition, the sensitivity of hTERT
was superior to that of other test (76%), although specificity and positive and negative predictive values were better for cytology (94%, 88.4% and 72.3% respectively) and NMP22 (88%, 80.6% and 73.3% respectively).
hTERT
mRNA levels in urine were higher in patients with bladder tumors compared to patients with a history of bladder tumor and with negative cystoscopy, as well as in the control group. This determination showed a higher diagnostic yield compared with the detection of NMP22 and urinary cytology.</description><identifier>EISSN: 2173-5786</identifier><identifier>DOI: 10.1016/j.acuro.2018.02.002</identifier><identifier>PMID: 29631914</identifier><language>eng ; spa</language><publisher>Spain</publisher><subject>Aged ; Biomarkers, Tumor - urine ; Female ; Humans ; Male ; Nuclear Proteins - urine ; Prospective Studies ; RNA, Messenger - urine ; Telomerase - genetics ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - urine</subject><ispartof>Actas urológicas españolas (English ed.), 2018-10, Vol.42 (8), p.524-530</ispartof><rights>Copyright © 2018 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29631914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>March-Villalba, J A</creatorcontrib><creatorcontrib>Panach-Navarrete, J</creatorcontrib><creatorcontrib>Herrero-Cervera, M J</creatorcontrib><creatorcontrib>Aliño-Pellicer, S</creatorcontrib><creatorcontrib>Martínez-Jabaloyas, J M</creatorcontrib><title>hTERT mRNA expression in urine as a useful diagnostic tool in bladder cancer. Comparison with cytology and NMP22 BladderCheck Test</title><title>Actas urológicas españolas (English ed.)</title><addtitle>Actas Urol Esp (Engl Ed)</addtitle><description>To study the relationship between quantitative mRNA determination (hTERT) in patients with bladder tumor, history of bladder tumor, and in subjects without a history of this neoplasia.
A prospective randomized controlled study with 91 subjects included. The value of mRNA-hTERT
was determined in 63 patients with a history or suspicion of bladder tumor and in 28 controls. Urine samples were sent for evaluation of the mRNA level (hTERT), the cytological study and the NMP22 result.
Differences were observed in mean hTERT
levels in each of the groups: tumor presence 21.33+/- 40.66, tumor history 2.16+/- 2.67, controls 0.9+/- 1, 75 (p<0.001). In patients with tumor, there was no difference in mean hTERT
levels between the different grades and stages, although there was a tendency: low grade tumor 9.04+/- 16.95, high grade 28.95+/- 48.36 (p=.069), stage Ta 10.33+/- 19.39, T1 17.88+/- 27.14, T2 54.8+/- 74.05 (p=.056). In addition, the sensitivity of hTERT
was superior to that of other test (76%), although specificity and positive and negative predictive values were better for cytology (94%, 88.4% and 72.3% respectively) and NMP22 (88%, 80.6% and 73.3% respectively).
hTERT
mRNA levels in urine were higher in patients with bladder tumors compared to patients with a history of bladder tumor and with negative cystoscopy, as well as in the control group. This determination showed a higher diagnostic yield compared with the detection of NMP22 and urinary cytology.</description><subject>Aged</subject><subject>Biomarkers, Tumor - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Nuclear Proteins - urine</subject><subject>Prospective Studies</subject><subject>RNA, Messenger - urine</subject><subject>Telomerase - genetics</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - urine</subject><issn>2173-5786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAQRS0kRKvSL0BCXrJp8CMvL0tUHlIpqMo-cuxJ65LEwU4E3fLlBLXczWzOnNFchG4oCSih8f0hkGpwNmCEpgFhASHsAk0ZTfgiStJ4gubeH8iYOOSR4FdowkTMqaDhFP3s89U2x812s8Tw3Tnw3tgWmxYPzrSApccSDx6qocbayF1rfW8U7q2t_6CyllqDw0q2ClyAM9t00hk_Kr5Mv8fq2Nva7o5YthpvXt8Zww-nlWwP6gPn4PtrdFnJ2sP8PGcof1zl2fNi_fb0ki3Xi45R2i90FYacCa5Aa041ISkkIhEiThIC4fizUFyqMI3SSsgqkpSwEuIojECKMpV8hu5O2s7Zz2G8WzTGK6hr2YIdfMEI4wmLWcpH9PaMDmUDuuicaaQ7Fv-18V-joG9e</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>March-Villalba, J A</creator><creator>Panach-Navarrete, J</creator><creator>Herrero-Cervera, M J</creator><creator>Aliño-Pellicer, S</creator><creator>Martínez-Jabaloyas, J M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>hTERT mRNA expression in urine as a useful diagnostic tool in bladder cancer. Comparison with cytology and NMP22 BladderCheck Test</title><author>March-Villalba, J A ; Panach-Navarrete, J ; Herrero-Cervera, M J ; Aliño-Pellicer, S ; Martínez-Jabaloyas, J M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-df443293cedd31d008e797996770e40029c3ac4858f9af5a102be6545ea9b8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; spa</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Biomarkers, Tumor - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Nuclear Proteins - urine</topic><topic>Prospective Studies</topic><topic>RNA, Messenger - urine</topic><topic>Telomerase - genetics</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>March-Villalba, J A</creatorcontrib><creatorcontrib>Panach-Navarrete, J</creatorcontrib><creatorcontrib>Herrero-Cervera, M J</creatorcontrib><creatorcontrib>Aliño-Pellicer, S</creatorcontrib><creatorcontrib>Martínez-Jabaloyas, J M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Actas urológicas españolas (English ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>March-Villalba, J A</au><au>Panach-Navarrete, J</au><au>Herrero-Cervera, M J</au><au>Aliño-Pellicer, S</au><au>Martínez-Jabaloyas, J M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>hTERT mRNA expression in urine as a useful diagnostic tool in bladder cancer. Comparison with cytology and NMP22 BladderCheck Test</atitle><jtitle>Actas urológicas españolas (English ed.)</jtitle><addtitle>Actas Urol Esp (Engl Ed)</addtitle><date>2018-10</date><risdate>2018</risdate><volume>42</volume><issue>8</issue><spage>524</spage><epage>530</epage><pages>524-530</pages><eissn>2173-5786</eissn><abstract>To study the relationship between quantitative mRNA determination (hTERT) in patients with bladder tumor, history of bladder tumor, and in subjects without a history of this neoplasia.
A prospective randomized controlled study with 91 subjects included. The value of mRNA-hTERT
was determined in 63 patients with a history or suspicion of bladder tumor and in 28 controls. Urine samples were sent for evaluation of the mRNA level (hTERT), the cytological study and the NMP22 result.
Differences were observed in mean hTERT
levels in each of the groups: tumor presence 21.33+/- 40.66, tumor history 2.16+/- 2.67, controls 0.9+/- 1, 75 (p<0.001). In patients with tumor, there was no difference in mean hTERT
levels between the different grades and stages, although there was a tendency: low grade tumor 9.04+/- 16.95, high grade 28.95+/- 48.36 (p=.069), stage Ta 10.33+/- 19.39, T1 17.88+/- 27.14, T2 54.8+/- 74.05 (p=.056). In addition, the sensitivity of hTERT
was superior to that of other test (76%), although specificity and positive and negative predictive values were better for cytology (94%, 88.4% and 72.3% respectively) and NMP22 (88%, 80.6% and 73.3% respectively).
hTERT
mRNA levels in urine were higher in patients with bladder tumors compared to patients with a history of bladder tumor and with negative cystoscopy, as well as in the control group. This determination showed a higher diagnostic yield compared with the detection of NMP22 and urinary cytology.</abstract><cop>Spain</cop><pmid>29631914</pmid><doi>10.1016/j.acuro.2018.02.002</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2173-5786 |
| ispartof | Actas urológicas españolas (English ed.), 2018-10, Vol.42 (8), p.524-530 |
| issn | 2173-5786 |
| language | eng ; spa |
| recordid | cdi_proquest_miscellaneous_2023726283 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Biomarkers, Tumor - urine Female Humans Male Nuclear Proteins - urine Prospective Studies RNA, Messenger - urine Telomerase - genetics Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - urine |
| title | hTERT mRNA expression in urine as a useful diagnostic tool in bladder cancer. Comparison with cytology and NMP22 BladderCheck Test |
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