hTERT mRNA expression in urine as a useful diagnostic tool in bladder cancer. Comparison with cytology and NMP22 BladderCheck Test

To study the relationship between quantitative mRNA determination (hTERT) in patients with bladder tumor, history of bladder tumor, and in subjects without a history of this neoplasia. A prospective randomized controlled study with 91 subjects included. The value of mRNA-hTERT was determined in 63 p...

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Veröffentlicht in:	Actas urológicas españolas (English ed.) 2018-10, Vol.42 (8), p.524-530
Hauptverfasser:	March-Villalba, J A, Panach-Navarrete, J, Herrero-Cervera, M J, Aliño-Pellicer, S, Martínez-Jabaloyas, J M
Format:	Artikel
Sprache:	eng ; spa
Schlagworte:	Aged Biomarkers, Tumor - urine Female Humans Male Nuclear Proteins - urine Prospective Studies RNA, Messenger - urine Telomerase - genetics Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - urine
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Zusammenfassung:	To study the relationship between quantitative mRNA determination (hTERT) in patients with bladder tumor, history of bladder tumor, and in subjects without a history of this neoplasia. A prospective randomized controlled study with 91 subjects included. The value of mRNA-hTERT was determined in 63 patients with a history or suspicion of bladder tumor and in 28 controls. Urine samples were sent for evaluation of the mRNA level (hTERT), the cytological study and the NMP22 result. Differences were observed in mean hTERT levels in each of the groups: tumor presence 21.33+/- 40.66, tumor history 2.16+/- 2.67, controls 0.9+/- 1, 75 (p
ISSN:	2173-5786
DOI:	10.1016/j.acuro.2018.02.002