Structure and Functions of the Mediator Complex

Structure and Functions of the Mediator Complex

Mediator is a key factor in the regulation of expression of RNA polymerase II-transcribed genes. Recent studies have shown that Mediator acts as a coordinator of transcription activation and participates in maintaining chromatin architecture in the cell nucleus. In this review, we present current co...

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Veröffentlicht in:Biochemistry (Moscow) 2018-04, Vol.83 (4), p.423-436
Hauptverfasser: Putlyaev, E. V., Ibragimov, A. N., Lebedeva, L. A., Georgiev, P. G., Shidlovskii, Y. V.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Chromatin
DNA-directed RNA polymerase
Gene expression
Genetic aspects
Genetic regulation
Genetic research
Life Sciences
Microbiology
Nuclei
Nuclei (cytology)
Proteins
Review
Ribonucleic acid
RNA
RNA polymerase
RNA polymerase II
RNA polymerases
Transcription activation
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Beschreibung
Zusammenfassung:Mediator is a key factor in the regulation of expression of RNA polymerase II-transcribed genes. Recent studies have shown that Mediator acts as a coordinator of transcription activation and participates in maintaining chromatin architecture in the cell nucleus. In this review, we present current concepts on the structure and functions of Mediator.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297918040132