Effects of konjac glucomannan on the structure, properties, and drug release characteristics of agarose hydrogels

[Display omitted] •AG-KGM composite hydrogels were prepared though a simple method.•Rheological tests showed KGM can make AG hydrogels more flexible.•KGM showed significant influences on the properties and structure of AG hydrogel.•KGM could effective relieve the burst release behavior of AG hydroge...

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Veröffentlicht in:Carbohydrate polymers 2018-06, Vol.190, p.196-203
Hauptverfasser: Yuan, Yi, Wang, Lin, Mu, Ruo-Jun, Gong, Jingni, Wang, Yuyan, Li, Yuanzhao, Ma, Jiaqi, Pang, Jie, Wu, Chunhua
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Sprache:eng
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Zusammenfassung:[Display omitted] •AG-KGM composite hydrogels were prepared though a simple method.•Rheological tests showed KGM can make AG hydrogels more flexible.•KGM showed significant influences on the properties and structure of AG hydrogel.•KGM could effective relieve the burst release behavior of AG hydrogel. Pure agarose (AG) hydrogels have strong rigidity and brittleness, which greatly limit their applications. Therefore, in this study, konjac glucomannan (KGM) was used to improve the properties of AG hydrogels. The effect of KGM on the structure and properties of AG hydrogels was investigated by rotational rheometry, Fourier Transform Infrared Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy. The results showed that the flexibility of the composite hydrogels increases with KGM concentration, which may be attributed to a synergistic interaction between KGM and AG resulting in a compact network structure. In vitro drug release behavior of composite hydrogels was investigated under different environments using model drug ciprofloxacin. The results showed that the encapsulation, drug loading efficiencies, and sustained release capacity of AG hydrogels were enhanced by the incorporation of KGM. These results suggested that KGM has the potential to enhance the properties and drug release characteristics of AG hydrogels.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2018.02.049