Effects of pharmacological reversal of hyperuricemia on features of the metabolic syndrome in patients with gouty arthritis

Effects of pharmacological reversal of hyperuricemia on features of the metabolic syndrome in patients with gouty arthritis

Hyperuricemia has been associated in epidemiological studies with the development of obesity, hypertension, insulin resistance and type 2 diabetes. Nevertheless, it remains unclear whether lowering of serum uric acid (UA) alters any of the features of the metabolic syndrome. In this prospective stud...

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Veröffentlicht in:Journal of investigative medicine 2018-10, Vol.66 (7), p.1031-1036
Hauptverfasser: Marin, Mariana, Maalouf, Naim M
Format: Artikel
Sprache:eng
Schlagworte:
Arthritis
Blood pressure
Diabetes
Drug dosages
Fasting
Heart failure
Hypertension
Insulin resistance
Internal medicine
Kidney diseases
Metabolic syndrome
Studies
Systematic review
Uric acid
Urine
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Zusammenfassung:Hyperuricemia has been associated in epidemiological studies with the development of obesity, hypertension, insulin resistance and type 2 diabetes. Nevertheless, it remains unclear whether lowering of serum uric acid (UA) alters any of the features of the metabolic syndrome. In this prospective study (ClinicalTrials.gov identifier: NCT01654276), 24 patients with gouty arthritis and hyperuricemia were treated for 6 months with the xanthine oxidase inhibitor febuxostat to lower serum UA to
ISSN:1081-5589
1708-8267
DOI:10.1136/jim-2018-000728