Cobalt-Catalyzed Diastereoselective Cross-Couplings between Alkynylzinc Pivalates and Functionalized Cyclic Iodides or Bromides

Cobalt-Catalyzed Diastereoselective Cross-Couplings between Alkynylzinc Pivalates and Functionalized Cyclic Iodides or Bromides

Various 1,2-, 1,3-, and 1,4-substituted cyclic iodides or bromides undergo highly diastereoselective cross-couplings (diastereoselectivity (dr) up to 99:1) with a range of alkynylzinc pivalates, using CoCl2 (20 mol %) and trans-N,N,N′,N′-tetramethylcyclohexane-1,2-diamine as a catalytic system....

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Veröffentlicht in:Organic letters 2018-04, Vol.20 (8), p.2441-2444
Hauptverfasser: Thomas, Lucie, Lutter, Ferdinand H, Hofmayer, Maximilian S, Karaghiosoff, Konstantin, Knochel, Paul
Format: Artikel
Sprache:eng
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Zusammenfassung:Various 1,2-, 1,3-, and 1,4-substituted cyclic iodides or bromides undergo highly diastereoselective cross-couplings (diastereoselectivity (dr) up to 99:1) with a range of alkynylzinc pivalates, using CoCl2 (20 mol %) and trans-N,N,N′,N′-tetramethylcyclohexane-1,2-diamine as a catalytic system.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b00784