Recognition and management of methemoglobinemia and hemolysis in a G6PD‐deficient patient on experimental anticancer drug Triapine
We report occurrence of severe methemoglobinemia in a patient on novel experimental anti‐cancer drug, Triapine. Treatment with methylene blue led to massive hemolysis due to concomitant G6PD deficiency. We recommend that G6PD screening be done in high‐risk populations prior to commencement of Triapi...
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| Veröffentlicht in: | American journal of hematology 2006-03, Vol.81 (3), p.210-211 |
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| container_title | American journal of hematology |
| container_volume | 81 |
| creator | Foltz, Lynda M. Dalal, Bakul I. Wadsworth, Louis D. Broady, Raewyn Chi, Kim Eisenhauer, Elizabeth Kobayashi, Ken Kollmannsburger, Christian |
| description | We report occurrence of severe methemoglobinemia in a patient on novel experimental anti‐cancer drug, Triapine. Treatment with methylene blue led to massive hemolysis due to concomitant G6PD deficiency. We recommend that G6PD screening be done in high‐risk populations prior to commencement of Triapine therapy. Am. J. Hematol. 81:210–211, 2006. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajh.20547 |
| format | Article |
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Treatment with methylene blue led to massive hemolysis due to concomitant G6PD deficiency. We recommend that G6PD screening be done in high‐risk populations prior to commencement of Triapine therapy. Am. J. Hematol. 81:210–211, 2006. © 2006 Wiley‐Liss, Inc.</description><subject>Anemias. Hemoglobinopathies</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Renal Cell - complications</subject><subject>Carcinoma, Renal Cell - drug therapy</subject><subject>Diseases of red blood cells</subject><subject>experimental anti‐cancer drug</subject><subject>G6PD deficiency</subject><subject>G6PD screening</subject><subject>Glucosephosphate Dehydrogenase Deficiency - complications</subject><subject>Hematologic and hematopoietic diseases</subject><subject>hemolysis</subject><subject>Hemolysis - drug effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Methemoglobinemia - chemically induced</subject><subject>Middle Aged</subject><subject>Pyridines - administration & dosage</subject><subject>Pyridines - adverse effects</subject><subject>severe methemoglobinemia</subject><subject>Thiosemicarbazones - administration & dosage</subject><subject>Thiosemicarbazones - adverse effects</subject><subject>Triapine</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKJDEUhoM4aHtZ-AJSGwdctJ6kUpXKUtrrIIyIrovTyak2UjeTapzeufAB5hnnSUxfwNWsTgjf_x_Ox9gRhzMOIM7x9eVMQCbVFhtx0Pm4yDOxzUaQ5jy-Qe-yvRBeATiXBeywXZ5LneagRuzzkUw3a93gujbB1iYNtjijhtoh6aqkoeGFmm5Wd1PXUuNwxSy_6kVwIXExlNzkD5f_Pv5aqpxxy2CPw2rGSvrTk3fLOqxjdnAGW0M-sX4-S568wz72HrAfFdaBDjdznz1fXz1Nbsf3v2_uJhf3YyOLTI2rylhlNVcGBSIYmRquCaekuCCZai5RUCq41aB1VlhDQlZTQ9wqBchtus9-rnt7373NKQxl44KhusaWunkoBQjBQRYRPF2DxncheKrKPh6BflFyKJfKy6i8XCmP7PGmdD5tyH6TG8cRONkAGAzWlY8GXPjmVJapVMnIna-5d1fT4v8by4tft-vVX46Dm3o</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Foltz, Lynda M.</creator><creator>Dalal, Bakul I.</creator><creator>Wadsworth, Louis D.</creator><creator>Broady, Raewyn</creator><creator>Chi, Kim</creator><creator>Eisenhauer, Elizabeth</creator><creator>Kobayashi, Ken</creator><creator>Kollmannsburger, Christian</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>200603</creationdate><title>Recognition and management of methemoglobinemia and hemolysis in a G6PD‐deficient patient on experimental anticancer drug Triapine</title><author>Foltz, Lynda M. ; Dalal, Bakul I. ; Wadsworth, Louis D. ; Broady, Raewyn ; Chi, Kim ; Eisenhauer, Elizabeth ; Kobayashi, Ken ; Kollmannsburger, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4857-ffcd7d917ca2aa0c43c19eabe712e43914a2e321d909958dce24fbce1d770a1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anemias. Hemoglobinopathies</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Renal Cell - complications</topic><topic>Carcinoma, Renal Cell - drug therapy</topic><topic>Diseases of red blood cells</topic><topic>experimental anti‐cancer drug</topic><topic>G6PD deficiency</topic><topic>G6PD screening</topic><topic>Glucosephosphate Dehydrogenase Deficiency - complications</topic><topic>Hematologic and hematopoietic diseases</topic><topic>hemolysis</topic><topic>Hemolysis - drug effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Methemoglobinemia - chemically induced</topic><topic>Middle Aged</topic><topic>Pyridines - administration & dosage</topic><topic>Pyridines - adverse effects</topic><topic>severe methemoglobinemia</topic><topic>Thiosemicarbazones - administration & dosage</topic><topic>Thiosemicarbazones - adverse effects</topic><topic>Triapine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foltz, Lynda M.</creatorcontrib><creatorcontrib>Dalal, Bakul I.</creatorcontrib><creatorcontrib>Wadsworth, Louis D.</creatorcontrib><creatorcontrib>Broady, Raewyn</creatorcontrib><creatorcontrib>Chi, Kim</creatorcontrib><creatorcontrib>Eisenhauer, Elizabeth</creatorcontrib><creatorcontrib>Kobayashi, Ken</creatorcontrib><creatorcontrib>Kollmannsburger, Christian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foltz, Lynda M.</au><au>Dalal, Bakul I.</au><au>Wadsworth, Louis D.</au><au>Broady, Raewyn</au><au>Chi, Kim</au><au>Eisenhauer, Elizabeth</au><au>Kobayashi, Ken</au><au>Kollmannsburger, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recognition and management of methemoglobinemia and hemolysis in a G6PD‐deficient patient on experimental anticancer drug Triapine</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>2006-03</date><risdate>2006</risdate><volume>81</volume><issue>3</issue><spage>210</spage><epage>211</epage><pages>210-211</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>We report occurrence of severe methemoglobinemia in a patient on novel experimental anti‐cancer drug, Triapine. Treatment with methylene blue led to massive hemolysis due to concomitant G6PD deficiency. We recommend that G6PD screening be done in high‐risk populations prior to commencement of Triapine therapy. Am. J. Hematol. 81:210–211, 2006. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16493607</pmid><doi>10.1002/ajh.20547</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Anemias. Hemoglobinopathies Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Biological and medical sciences Carcinoma, Renal Cell - complications Carcinoma, Renal Cell - drug therapy Diseases of red blood cells experimental anti‐cancer drug G6PD deficiency G6PD screening Glucosephosphate Dehydrogenase Deficiency - complications Hematologic and hematopoietic diseases hemolysis Hemolysis - drug effects Humans Medical sciences Methemoglobinemia - chemically induced Middle Aged Pyridines - administration & dosage Pyridines - adverse effects severe methemoglobinemia Thiosemicarbazones - administration & dosage Thiosemicarbazones - adverse effects Triapine |
| title | Recognition and management of methemoglobinemia and hemolysis in a G6PD‐deficient patient on experimental anticancer drug Triapine |
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