Recognition and management of methemoglobinemia and hemolysis in a G6PD‐deficient patient on experimental anticancer drug Triapine

We report occurrence of severe methemoglobinemia in a patient on novel experimental anti‐cancer drug, Triapine. Treatment with methylene blue led to massive hemolysis due to concomitant G6PD deficiency. We recommend that G6PD screening be done in high‐risk populations prior to commencement of Triapi...

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Veröffentlicht in:	American journal of hematology 2006-03, Vol.81 (3), p.210-211
Hauptverfasser:	Foltz, Lynda M., Dalal, Bakul I., Wadsworth, Louis D., Broady, Raewyn, Chi, Kim, Eisenhauer, Elizabeth, Kobayashi, Ken, Kollmannsburger, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemias. Hemoglobinopathies Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Biological and medical sciences Carcinoma, Renal Cell - complications Carcinoma, Renal Cell - drug therapy Diseases of red blood cells experimental anti‐cancer drug G6PD deficiency G6PD screening Glucosephosphate Dehydrogenase Deficiency - complications Hematologic and hematopoietic diseases hemolysis Hemolysis - drug effects Humans Medical sciences Methemoglobinemia - chemically induced Middle Aged Pyridines - administration & dosage Pyridines - adverse effects severe methemoglobinemia Thiosemicarbazones - administration & dosage Thiosemicarbazones - adverse effects Triapine
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Zusammenfassung:	We report occurrence of severe methemoglobinemia in a patient on novel experimental anti‐cancer drug, Triapine. Treatment with methylene blue led to massive hemolysis due to concomitant G6PD deficiency. We recommend that G6PD screening be done in high‐risk populations prior to commencement of Triapine therapy. Am. J. Hematol. 81:210–211, 2006. © 2006 Wiley‐Liss, Inc.
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.20547