Next-generation small molecule therapies for heart failure: 2015 and beyond

[Display omitted] Poor prognosis coupled with significant economic burden makes heart failure (HF) one of the largest issues currently facing the world population. Although a significant number of new therapies have emerged over the past 20 years to treat the underlying physiological risk factors, o...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2018-05, Vol.28 (9), p.1429-1435
Hauptverfasser:	Malinowski, Justin T., St. Jean, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical development Heart failure Heart Failure - diagnosis Heart Failure - drug therapy Humans Molecular Structure Next generation Small molecule Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - therapeutic use
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Zusammenfassung:	[Display omitted] Poor prognosis coupled with significant economic burden makes heart failure (HF) one of the largest issues currently facing the world population. Although a significant number of new therapies have emerged over the past 20 years to treat the underlying physiological risk factors, only two new medications specifically for HF have been approved since 2007. This perspective provides an overview of recently approved treatment options for HF and as well as an update on additional small molecule therapies currently in clinical development.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2018.03.064